The Validity of Using Human Squamous Cell Carcinoma Associated Antigen and Cytokeratin 19 Fragment Antigen 21-1 to Predict Postoperative Adjuvant Radiotherapy for Nonbulky Early-Stage Squamous Cell Carcinoma of the Cervix

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Chan-Zhen LiuJie-Qing Zhang

Abstract

There are no generally accepted biomarkers for the optimal selection of radiotherapy-based or surgical-based treatment options for nonbulky early-stage squamous cell carcinoma of the cervix (IA1-IB1 and IIA1). The objective of this study was to assess the value of human squamous cell carcinoma-associated antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) in evaluation of patients with nonbulky early-stage squamous cell carcinoma of the cervix to determine if radiotherapy is warranted after radical surgery. Patients with stage IA1-IB1 and IIA1 squamous cell carcinoma of the cervix who were treated at the Department of Gynecological Oncology, Affiliated Tumor Hospital of Guangxi Medical University, from March 2012 to August 2014 (n = 308) were treated with radical hysterectomy and pelvic lymphadenectomy. The levels of SCC-Ag and CYFRA21-1 were detected by enzyme-linked immunosorbent assay before surgery. The relationship between the concentrations of SCC-Ag and CYFRA21-1 and risk factors was estimated through logistic regression and analysis of variance t test. The cutoff values of these 2 markers to evaluate the need for postoperative radiotherapy were identified and validated by receiver operating characteris...Continue Reading

References

Dec 1, 1976·American Journal of Obstetrics and Gynecology·G W Morley, J C Seski
Dec 28, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R A Samlal, J van der Velden
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·M LeinS A Loening
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Jun 28, 2000·Journal of Cancer Research and Clinical Oncology·Y SuzukiH Tsujii
Aug 31, 2004·Annals of Clinical Biochemistry·Michael J Duffy
May 3, 2005·Gynecologic Oncology·Rodney P RocconiJ Michael Straughn
May 24, 2008·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elvira M DavelaarPeter Kenemans
Jun 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Silvia Rodríguez VillalbaJosé Manuel Cervera Grau
Sep 3, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Korapin RudtanasudjatumSumalee Siriaunkgul
May 3, 2013·Obstetrics and Gynecology·Neville F HackerMichael Jackson
Jan 8, 2015·Scientific Reports·Chanzhen LiuKehkooi Kee
Apr 15, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Wui-Jin KohJillian L Scavone
Dec 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li PengGuan-Cheng Li
Nov 22, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ping SunFu-Jiao Duan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.