The value and significance of 25(OH) and 1,25(OH) vitamin D serum levels in adult coeliac patients: A review of the literature

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Fabiana Zingone, Carolina Ciacci

Abstract

Within the wide spectrum of symptoms and alteration of systems that characterizes CeD, several studies indicate a low-level of vitamin D, therefore recent guidelines suggest its evaluation at the time of diagnosis. This review examines the data from existing studies in which vitamin D has been assessed in CeD patients. Our review indicates that most of the studies on vitamin D in adult CeD report a 25 (OH) vitamin D deficiency at diagnosis that disappears when the patient goes on a gluten-free diet, independently of any supplementation. Instead, when the calcitriol, the active 1,25 (OH) vitamin D form, was evaluated, it resulted in the normal range at the time of CeD diagnosis. A strict and lifelong gluten-free diet can help recover vitamin D level without any supplementation.

Citations

Jun 18, 2020·Nutrients·Jovana KnezevicKarin Amrein
Aug 17, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chiara TortoraFrancesca Rossi
Oct 24, 2020·Journal of Pediatric Gastroenterology and Nutrition·Chiara TortoraFrancesca Rossi
Mar 19, 2019·BMJ Nutrition, Prevention & Health·Fabiana ZingoneCarolina Ciacci

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