The value of a histamine H2-receptor antagonist in the management of patients with the Zollinger-Ellison syndrome

The New England Journal of Medicine
C T Richardson, J H Walsh


Inhibition of acid secretion by an H2-receptor antagonist (metiamide) was assessed in three patients with the Zollinger-Ellison syndrome. Metiamide (200 or 300 mg) inhibited acid secretion transiently (2 1/2 hours) by 85 to 100 per cent in all patients. Although anticholinergic drugs alone inhibited acid secretion by only 0 to 35 per cent in these patients, the combination of metiamide and anticholinergic markedly prolonged the inhibitory effect of metiamide. Total gastrectomy was refused by one patient, and was impossible in another; both were treated with metiamide and anticholinergic for five and 10 months. A third patient was treated with metiamide and anticholinergic for three weeks in preparation for total gastrectomy. Ulcer pain and diarrhea disappeared, and each gained weight. H2-receptor antagonists may be useful in the treatment of some patients with the Zollinger-Ellison syndrome.


Feb 15, 1975·Lancet·J A ForrestL R Celestin
Apr 21, 1972·Nature·J W BlackE M Parsons
Apr 1, 1956·A.M.A. Archives of Internal Medicine·D C SUN, H SHAY


Apr 1, 1982·Digestive Diseases and Sciences·D M McCarthy, P E Hyman
Feb 1, 1993·Digestive Diseases and Sciences·D C MetzR T Jensen
Apr 1, 1984·Digestive Diseases and Sciences·R T Jensen
Nov 1, 1982·World Journal of Surgery·N W HarrisD C Carter
Mar 1, 1982·Regulatory Peptides·V SchusdziarraR H Unger
Dec 20, 1990·The New England Journal of Medicine·M Feldman, M E Burton
Jul 1, 1977·British Journal of Pharmacology·M M Dale
Jan 1, 1977·World Journal of Surgery·C G Clark, J H Wyllie
Jan 1, 1983·American Journal of Surgery·B E StabileE Passaro
Sep 1, 1979·American Journal of Surgery·S A CraneW G Heeringa
Oct 24, 1986·The American Journal of Medicine·R VinayekR T Jensen
Aug 5, 2009·Journal of Surgical Oncology·Meei J Yeung, Janice L Pasieka
Jan 26, 2006·Expert Opinion on Pharmacotherapy·Jose M Nieto, Joseph R Pisegna
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·L Bardram, F Stadil
Jul 15, 2015·Pancreas·Brian P RiffD C Metz
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·N A AhmadD C Metz
Jul 1, 1980·Postgraduate Medicine·J B Marshall, R H Settles
Jan 1, 1977·World Journal of Surgery·M I Grossman

Related Concepts

Drug Evaluation
Antihistamines, Classical
Metiamide Monohydrochloride
Receptors, Drug
Zollinger-Ellison Syndrome

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.