The value of a multiplexed gastrointestinal pathogen panel in 2 distinct patient populations

Diagnostic Microbiology and Infectious Disease
Jonas PettersonRosemary She

Abstract

We assess the value of the Luminex xTAG Gastrointestinal Pathogen Panel (GPP) in 2 different patient populations: an uninsured, indigent population seeking primary care, and a tertiary care hospital specializing in surgical, transplant, and oncology care. Stool specimens collected April to August 2013 for infectious workup were tested on the GPP, and discordant results were further analyzed by alternative methods. Compared to the tertiary care setting, stool pathogen detection was nearly twice as frequent in the primary care setting (25% versus 14%; P<0.05) with a broader array of pathogens detected (15 versus 4). Overall, the greatest value of the GPP was in detection of viral causes of gastroenteritis that were not routinely sought and in detection of Campylobacter spp. when patients presented late in the disease course. Application of a GPP should consider the characteristics of the patient population to maximize its clinical utility in different healthcare settings.

References

Jan 7, 2011·Journal of Clinical Microbiology·Emilie BessèdeFrancis Mégraud
Nov 28, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E HalliganS Goldenberg
Mar 14, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y ZboromyrskaJ Vila
Mar 10, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·C VocaleV Sambri
Sep 1, 2015·The Journal of Molecular Diagnostics : JMD·Zhengming GuRandall T Hayden

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