Abstract
Several coagulation parameters and plasminogen levels were studied in 80 normal people divided into eight paired and sex-matched age groups: prepubertal children, postpubertal children, young adults, and adults over 50. The data indicate that factor-VII and -IX activities increase with age, with a cluster of lower activity for children and higher activity for adults. Factor-VIII levels appear to decrease with age, although this effect could be due to greater anxiety in the pre- and postpubertal children at the time of venipuncture. The adults showed no significant change in factor-VIII activity with age, but partial data indicate that factor-VIII levels are higher in adults with blood group A than those with blood group O. The age-related changes in factor-VII, -IX, and possibly -VIII activities did not vary between sexes. By contrast, plasminogen increased strikingly with age in males and decreased with age in females. With fibrinogen, a similar effect was found for adults, though not for the entire population. These findings indicate the importance of using appropriate age- and sex-matched controls for coagulation and plasminogen assays, especially in patients with mild inherited or acquired coagulation disorders.
References
Feb 1, 1975·British Journal of Haematology·C A HallW J Dodds
Jan 9, 1971·Lancet·D J MantleM P Vessey
Mar 12, 1966·Lancet·R ChakrabartiG M Clarke
Apr 1, 1968·The American Journal of Physiology·J M McKenzie, P R Fowler
Sep 1, 1972·Transfusion·A D Schwartz
Jun 1, 1970·British Journal of Haematology·M HillsM O Matchett
Oct 1, 1970·Journal of Clinical Pathology·J C FergusonG P McNicol
Sep 1, 1969·The American Journal of Physiology·W J Dodds
Aug 27, 1966·British Medical Journal·J D Cash
Mar 1, 1966·British Journal of Haematology·C B KerrR Biggs
Jul 1, 1967·The American Journal of Physiology·W J DoddsJ F Mustard
Jul 1, 1967·British Journal of Haematology·C MerskeyH Wohl
Apr 1, 1959·British Journal of Haematology·W R PITNEY, B J ARNOLD
Jul 1, 1960·British Journal of Haematology·A A COOPERBERG, J TEITELBAUM
Mar 1, 1961·Journal of Clinical Pathology·R HUME
Apr 1, 1961·The Journal of Physiology·G I INGRAM
Feb 1, 1961·Acta Haematologica·K W DENSON
Nov 1, 1960·The Journal of Clinical Investigation·S I RAPAPORTF J MOORE
Jul 1, 1961·The American Journal of Clinical Nutrition·A R Walker
Jul 1, 1962·British Journal of Haematology·N E SIMPSON, R BIGGS
Jan 1, 1963·The American Journal of Physiology·J M MCKENZIEM M GUEST
Jul 1, 1963·British Journal of Haematology·H T SWAN
Apr 1, 1964·British Journal of Haematology·A E PRESTON, A BARR
Dec 5, 1964·Lancet·D OGSTON, G M MCANDREW
Citations
Jul 9, 1999·The Journal of Pathology·B A LwaleedJ L Francis
Mar 1, 1978·Thrombosis Research·J C GoldsmithH R Roberts
Dec 12, 2001·British Journal of Haematology·G D Lowe
Nov 4, 1982·The New England Journal of Medicine·U SeligsohnE Zwang
Feb 1, 1975·British Journal of Haematology·C A HallW J Dodds
Jul 15, 2011·Vox Sanguinis·W MadlaJ Bux
Jun 1, 1987·Thrombosis Research·Y HashimotoA Takada
Jan 1, 1979·Thrombosis Research·M G MazzucconiG Mariani
Apr 15, 1988·Thrombosis Research·Y KomiyamaK Murata
Jun 1, 1981·Thrombosis Research·A G DettoriO Ponari
Jun 1, 1981·Thrombosis Research·O PonariA G Dettori
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stephan KöhlerMeinhard Kieser
Jan 1, 1986·Thrombosis Research·Y Calmus, A Robert
Jan 1, 1984·Clinical and Laboratory Haematology·M Bhavnani, D I Evans
Jan 1, 1982·Clinical and Laboratory Haematology·F RuizA V Swan
Jun 7, 2006·Drugs in R&D·Hellmut R D Wolf