The value of age- and sex-matched controls for coagulation studies.

British Journal of Haematology
W J DoddsC A Hall

Abstract

Several coagulation parameters and plasminogen levels were studied in 80 normal people divided into eight paired and sex-matched age groups: prepubertal children, postpubertal children, young adults, and adults over 50. The data indicate that factor-VII and -IX activities increase with age, with a cluster of lower activity for children and higher activity for adults. Factor-VIII levels appear to decrease with age, although this effect could be due to greater anxiety in the pre- and postpubertal children at the time of venipuncture. The adults showed no significant change in factor-VIII activity with age, but partial data indicate that factor-VIII levels are higher in adults with blood group A than those with blood group O. The age-related changes in factor-VII, -IX, and possibly -VIII activities did not vary between sexes. By contrast, plasminogen increased strikingly with age in males and decreased with age in females. With fibrinogen, a similar effect was found for adults, though not for the entire population. These findings indicate the importance of using appropriate age- and sex-matched controls for coagulation and plasminogen assays, especially in patients with mild inherited or acquired coagulation disorders.

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Citations

Jul 9, 1999·The Journal of Pathology·B A LwaleedJ L Francis
Mar 1, 1978·Thrombosis Research·J C GoldsmithH R Roberts
Dec 12, 2001·British Journal of Haematology·G D Lowe
Nov 4, 1982·The New England Journal of Medicine·U SeligsohnE Zwang
Feb 1, 1975·British Journal of Haematology·C A HallW J Dodds
Jun 1, 1987·Thrombosis Research·Y HashimotoA Takada
Jan 1, 1979·Thrombosis Research·M G MazzucconiG Mariani
Apr 15, 1988·Thrombosis Research·Y KomiyamaK Murata
May 29, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stephan KöhlerMeinhard Kieser
Jan 1, 1986·Thrombosis Research·Y Calmus, A Robert
Jan 1, 1984·Clinical and Laboratory Haematology·M Bhavnani, D I Evans
Jan 1, 1982·Clinical and Laboratory Haematology·F RuizA V Swan

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