PMID: 7546131Jul 1, 1995Paper

The value of anti-caries and anti-plaque dentifrices at a community level

Advances in Dental Research
K W Stephen

Abstract

Although dentifrices (in a modern sense) were first introduced at the turn of the century, it was not until the advent of fluoride-containing compounds that any of therapeutic value was produced. In the early post-war years, formulation compatibility difficulties occurred, with the result that none was demonstrated to have clinically proven efficacy until stannous fluoride was successfully incorporated in the "Crest" formulation of 1955. Thereafter, sodium monofluorophosphate (SMFP) appeared, to be followed by organic and acid-phosphate fluoride preparations, most of which were shown to produce clinical benefit over placebo controls. Since the late 1970's, however, such studies have been deemed unethical in many countries in view of the almost universal availability of efficacious fluoride dentifrices. While an NaF formulation was the first to be tested (albeit unsuccessfully) by Bibby (1945), there was a considerable time period before the arrival of both stable and effective silica-based systems in the early 1980's. Results of studies have varied, but the largest ever double-blind NaF/SMFP head-to-head dentifrice trial yet published (Stephen et al., 1994) has indicated a 6.4% significant benefit in favor of NaF (in silica) ov...Continue Reading

References

Jan 1, 1992·Caries Research·R K ChestersK W Stephen
Dec 1, 1988·The Journal of the American Dental Association·M E Jensen, F Kohout
Jan 1, 1969·Caries Research·Y Ericsson, B Forsman
Dec 1, 1945·Journal of Dental Research·B G BIBBY

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Citations

Aug 8, 2009·British Dental Journal·Anthony BlinkhornG J Seymour
Mar 23, 2002·Cadernos de saúde pública·Sônia Cristina Lima Chaves, Lígia Maria Vieira-Da-Silva

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