PMID: 11932892Apr 5, 2002Paper

The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast

Cancer
A C NeuschatzD E Wazer

Abstract

Margin width is considered the most important risk factor for local recurrence in ductal carcinoma in situ (DCIS) of the breast. The purpose of this report is to assess the predictive utility of lumpectomy specimen margin assessment for the presence and extent of residual DCIS. Specimens from 253 DCIS cases with lumpectomy and reexcision were studied to determine to the probability of residual DCIS on reexcision. The probability of residual tumor was evaluated with respect to tumor size, margin status, nuclear grade, presence of necrosis, patient age, and the extent of specimen processing (number of sections/volume tissue). Lesions were grouped by size: less than or equal to 2 mm, greater than 2-15 mm, greater than 15-40 mm, or greater than 40 mm. Margin width was recorded as the distance of DCIS to the closest specimen edge or, for positive margins, scored as: extensive (margin involvement in > or =8 sections or >4 low-power fields [LPFs]), moderate (5-7 sections or 2-4 LPFs), minimal (2-4 sections or 1 LPF), or focal (1 section, single focus). The amount of residual tumor was graded by maximum dimension on a semiquantitative basis. Initial excision margin significantly predicted for the presence of residual tumor on reexcisio...Continue Reading

References

Oct 1, 1989·International Journal of Radiation Oncology, Biology, Physics·R Schmidt-UllrichN J Robert
Jun 1, 1996·Cancer·M J SilversteinD N Poller
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D E WazerR Graham
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherM Kavanah
Jul 11, 1998·Cancer·S A Silver, F A Tavassoli
May 13, 1999·The New England Journal of Medicine·M J SilversteinW J Colburn
Jan 12, 2000·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G NoëlJ J Mazeron
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA A Martinez
Jul 21, 2000·Bulletin du cancer·G F SchwartzUNKNOWN Consensus Conference Committee
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N BijkerM J van de Vijver
May 18, 2001·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Noël, J J Mazeron

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Citations

Mar 5, 2009·Archives of Gynecology and Obstetrics·Nicolai MaassIvo Meinhold-Heerlein
Sep 29, 2007·Breast Cancer Research and Treatment·Neill PataniKefah Mokbel
Apr 4, 2008·Breast Cancer Research and Treatment·Alberto LuiniAntonio Frasson
Jan 28, 2004·Cancer Letters·Alessia BiscaGiuseppe Damante
Apr 20, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·V DoridotK B Clough
May 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sarah E Pinder
Apr 9, 2004·The New England Journal of Medicine·Harold J BursteinCarolyn M Kaelin
Feb 27, 2003·The Cancer Journal·Monica Morrow
Dec 6, 2005·The American Journal of Surgical Pathology·Dengfeng CaoPedram Argani
Dec 22, 2009·American Journal of Clinical Oncology·Laleh G MelstromDavid J Winchester
Mar 3, 2006·The Breast Journal·Chrisoula D ScopaChristina Aletra
Oct 8, 2005·BMJ : British Medical Journal·Malcolm R Kell, Monica Morrow
Jun 8, 2012·International Journal of Surgical Oncology·Kelly LambertKefah Mokbel
Jan 7, 2003·Annals of Surgical Oncology·Farbod DarvishianDwight C DeRisi
Oct 1, 2005·Annals of Surgical Oncology·Tehillah S MenesSharon Rosenbaum Smith
May 4, 2005·Annals of Surgical Oncology·Siegal SadetzkiMoshe Z Papa
Dec 8, 2006·Annals of Surgical Oncology·Pierre-Ludovic GiacaloneJean Pierre Daurés
Apr 20, 2007·Annals of Surgical Oncology·Mary F DillonNiall O'Higgins
Nov 8, 2007·Annals of Surgical Oncology·Shalini AroraShabnam Jaffer
Dec 18, 2009·Southern Medical Journal·Tsz Ting Law, Ava Kwong
Mar 2, 2005·The Lancet Oncology·Benjamin O AndersonMelvin J Silverstein
Aug 14, 2008·Expert Review of Anticancer Therapy·Monica Morrow
Oct 17, 2015·Annals of Surgical Oncology·Brandy L EdwardsAnneke T Schroen
Mar 24, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S O GurdalV Ozmen
Feb 18, 2011·The Breast : Official Journal of the European Society of Mastology·J-G FeronS Uzan
Nov 26, 2010·Surgical Oncology·Neill PataniKefah Mokbel
May 14, 2010·Cancer Treatment Reviews·Laura G EstévezIgnasi Tusquets
Aug 30, 2008·Journal of the American College of Surgeons·Laurie J KirsteinBarbara L Smith
Nov 21, 2007·The Breast : Official Journal of the European Society of Mastology·M E O'DonnellR A J Spence
Jun 5, 2007·International Journal of Radiation Oncology, Biology, Physics·Arjan P Schouten van der VeldenTheo Wobbes
May 15, 2007·The Surgical Clinics of North America·Martin J O'Sullivan, Monica Morrow
Jul 28, 2005·Cancer·Seth A KaufmanDavid E Wazer
Dec 17, 2008·NMR in Biomedicine·Carolyn MountfordPeter Malycha

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