The Value of Cardiopulmonary Exercise Testing in Determining Severity in Patients with both Systolic Heart Failure and COPD.

Scientific Reports
Cássia da Luz GoulartAudrey Borghi-Silva

Abstract

Our aim was to identify optimal cardiopulmonary exercise testing (CPET) threshold values that distinguish disease severity progression in patients with co-existing systolic heart failure (HF) and chronic obstructive pulmonary disease (COPD), and to evaluate the impact of the cut-off determined on the prognosis of hospitalizations. We evaluated 40 patients (30 men and 10 woman) with HF and COPD through pulmonary function testing, doppler echocardiography and maximal incremental CPET on a cycle ergometer. Several significant CPET threshold values were identified in detecting a forced expiratory volume in 1 second (FEV1) < 1.6 L: 1) oxygen uptake efficiency slope (OUES) < 1.3; and 2) circulatory power (CP) < 2383 mmHg.mlO2.kg-1. CPET significant threshold values in identifying a left ventricular ejection fraction (LVEF) < 39% were: 1) OUES: < 1.3; 2) CP < 2116 mmHg.mlO2.kg-1.min-1 and minute ventilation/carbon dioxide production (V̇E/V̇CO2) slope>38. The 15 (38%) patients hospitalized during follow-up (8 ± 2 months). In the hospitalizations analysis, LVEF < 39% and FEV1 < 1.6, OUES < 1.3, CP < 2116 mmHg.mlO2.kg-1.min-1 and V̇E/V̇CO2 > 38 were a strong risk predictor for hospitalization (P ≤ 0.050). The CPET response effectively id...Continue Reading

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Citations

Aug 5, 2020·Expert Review of Cardiovascular Therapy·Ross ArenaAntonio Abbate
Dec 3, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C L GoulartA Borghi-Silva
Feb 12, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Polliana B Dos SantosAudrey Borghi-Silva
Jun 5, 2021·Heart & Lung : the Journal of Critical Care·Giovana Salgado BaffaAudrey Borghi-Silva
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·J Alberto NederDenis E O'Donnell

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Statistical Package for the Social Sciences ( SPSS )

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