Jun 14, 1985

The value of combined determination of high molecular mass API and LP-X in the differential diagnosis of intrahepatic and extrahepatic obstruction

Clinica Chimica Acta; International Journal of Clinical Chemistry
J M Schut, D Diaz


Combined determination of serum lipoprotein-X and electrophoretic separation of high molecular mass (HMr) alkaline phosphatase has been proposed as a marker for the differential diagnosis between intrahepatic cholestasis and extrahepatic obstructive jaundice. Of 32 patients who were known to be lipoprotein-X positive and in whom a definitive diagnosis had been made, 13 had intrahepatic cholestasis and 17 extrahepatic obstruction, and 2 had both intrahepatic and extrahepatic obstruction. The detection of HMr alkaline phosphatase isoenzyme proved to be a sensitive and specific test for detecting liver disease, particularly obstructive liver disease. The diagnostic significance of the combined determination of serum lipoprotein-X to demonstrate or exclude cholestasis and electrophoretic separation of HMr alkaline phosphatase isoenzymes to allow differentiation between intrahepatic cholestasis and extrahepatic obstruction was investigated.

  • References19
  • Citations3


  • References19
  • Citations3


Mentioned in this Paper

Jaundice, Obstructive
Clinical Enzyme Tests (Procedure)
Alkaline Phosphatase Measurement
Alkaline phosphatase isoenzyme
Cholestasis, Extrahepatic
Alkaline Phosphatase
Differential Diagnosis
Intrahepatic Cholestasis
Cell Differentiation Process

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