Abstract
To discuss the clinical value of immunoglobulin gene rearrangements in the diagnosis of B-cell lymphoma. A total of 209 cases of B-cell lymphomas and 35 cases of reactive lymphoid hyperplasia were selected for DNA extraction and PCR amplification using the BIOMED-2 primer system. Gel electrophoresis of heteroduplexes was used to analyze immunoglobulin gene rearrangements. A total of 209 cases of B-cell lymphoma, including 69 extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue, 63 diffuse large B-cell lymphomas, 39 follicular lymphomas, 15 small lymphocytic lymphomas, 6 plasmacytomas, 6 mantle cell lymphomas, 7 nodal marginal zone B-cell lymphomas, and 4 lymphoplasmacytoid lymphomas, were examined. Immunoglobulin gene rearrangements were found in all 209 cases, with 93 IGHA, 122 IGHB, 98 IGHC, 167 IGK, 100 IGL, 167 IGHA/B/C, 204 IGH/IGK, 209 IGH/IGK/IGL, 129 IGH+IGK, 81 IGH+IGL, 83 IGK+IGL and 68 IGH+IGK+IGL gene rearrangements. Immunoglobulin gene rearrangements were not found in the 35 cases of reactive lymphoid hyperplasia. IGH and IGK gene rearrangements were mainly found in mantle cell lymphomas, small lymphocytic lymphomas, extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid t...Continue Reading
References
May 1, 1990·Journal of Clinical Pathology·K P McCarthyL M Wiedemann
Dec 4, 2002·Nature Reviews. Immunology·Hiroaki Niiro, Edward A Clark
Dec 13, 2003·Leukemia·J J M van DongenE A Macintyre
Oct 21, 2005·The Journal of Molecular Diagnostics : JMD·Yorick SandbergAnton W Langerak
Nov 25, 2005·Leukemia·R F McClureP J Kurtin
Dec 16, 2006·Leukemia·P A S EvansJ Cabeçadas
Dec 16, 2006·Leukemia·J H J M van KriekenJ J M van Dongen
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marko Radic
Oct 14, 2008·Current Opinion in Immunology·Eric Meffre, Hedda Wardemann
Jul 8, 2009·The Journal of Experimental Medicine·Emily J CaderaMark S Schlissel
Feb 3, 2012·Histopathology·Gustavo TapiaAurelio Ariza
Apr 24, 2012·Oncotarget·Renee C TschumperDiane F Jelinek
Dec 28, 2012·Journal of Virology·Felicia Anna TucciRalf Küppers
Jan 9, 2013·Methods in Molecular Biology·Christiane PottMichael Kneba
May 22, 2013·Journal of Pediatric Hematology/oncology·Jimmy T NguyenRicarchito Manera
Oct 31, 2013·Archives of Pathology & Laboratory Medicine·Brenda Ly, Claudiu V Cotta
Mar 14, 2014·Hematology·Behzad PoopakMohammad Shahjahani
Apr 5, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Cong-Wei JiaZhao-Hui Lu
May 13, 2014·International Journal of Laboratory Hematology·L LiuC Wang
May 28, 2014·Experimental Dermatology·Daniel HummeMarc Beyer
Jul 6, 2014·Radiology and Oncology·Ira KokovicSrdjan Novakovic
Oct 10, 2014·Genetic Testing and Molecular Biomarkers·Fatmeh AbbasRami Mahfouz
Dec 17, 2014·International Journal of Oncology·Ira KokovicSrdjan Novakovic
Dec 31, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Behzad PoopakNajmaldin Saki
May 2, 2015·Oncotarget·Graeme CowanSurinder S Sahota
Sep 1, 2015·Oncotarget·Desheng XiaoYongguang Tao
Oct 3, 2015·Oncotarget·Chong WangC Cameron Yin
Oct 28, 2015·Genetics and Molecular Research : GMR·J YaoL F Yin
Feb 6, 2016·Oncotarget·Seung Eun LeeYoung Hyeh Ko
Mar 5, 2016·Oncotarget·Marilisa MarinelliRobin Foà
Mar 19, 2016·Journal of Medical Virology·Yang ZhangYimou Wu
Apr 7, 2016·Oncotarget·Jiantao JiaYongguang Tao
Apr 7, 2016·Oncotarget·Olivia MariniCristina Tecchio
Jun 16, 2016·Cancer Research·Xiaozhen HeYongguang Tao
Jun 30, 2016·Genes, Chromosomes & Cancer·Claudia OttoUNKNOWN “Molecular Mechanisms in Malignant Lymphomas” Network Project
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Jian BoYu Zhao
Nov 20, 2016·Veterinary Immunology and Immunopathology·Elspeth M WaughJoanna S Morris
Dec 4, 2016·Hematology·Premal Lulla, Helen E Heslop
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marek SinkoraKaterina Stepanova