The value of diffusion kurtosis imaging in assessing pathological complete response to neoadjuvant chemoradiation therapy in rectal cancer: a comparison with conventional diffusion-weighted imaging

Oncotarget
Feixiang HuWeijun Peng

Abstract

The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3.0 T MRI scanner. Apparent diffusion coefficient (ADC), mean diffusion (MD) and mean kurtosis (MK) values of the tumor were measured in pre- and post-CRT phases and then compared to histopathologic findings after total mesorectal excision (TME). Both Mann-Whitney U-test and Kruskal-Wallis test were used as statistical methods. Diagnostic performance was determined using receiver operating characteristic (ROC) curve analysis. For a total of 56 rectal lesions (pCR, n = 14; non-pCR, n = 42), the MKpre and MKpost values were much lower for the pCR patients (mean±SD, 0.72±0.09 and 0.56±0.06, respectively) than those for the non-pCR patients (0.89±0.11 and 0.68±0.08, respectively) (p < 0.001). The ADCpost and the change ratio of apparent diffusion coefficient (ADCratio) values was signif...Continue Reading

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Citations

Apr 30, 2019·The Journal of International Medical Research·Vincenza GranataAntonella Petrillo
Jun 27, 2018·Nuclear Medicine and Molecular Imaging·Jeong Won Lee, Sang Mi Lee
Jul 20, 2019·Australasian Physical & Engineering Sciences in Medicine·Filipa BorlinhasHugo A Ferreira
Nov 16, 2018·The British Journal of Radiology·Niels W SchurinkRegina G H Beets-Tan
Oct 30, 2020·Frontiers in Oncology·Hester E HaakRegina G H Beets-Tan
Dec 28, 2021·NMR in Biomedicine·Lukas LundholmMaria Ljungberg

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Software Mentioned

Body Diffusion Toolbox
GRAPPA
SPSS Statistics
Medcalc

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