PMID: 9191517Jun 15, 1997Paper

The value of DNA flow cytometry in predicting the development of lymph node metastasis and survival in patients with locally recurrent oral squamous cell carcinoma

Cancer
J HemmerW F Van Heerden

Abstract

DNA flow cytometry studies of squamous cell carcinoma of the head and neck have shown that patients with diploid tumors have favorable prognoses, whereas the outcomes of those with, aneuploid tumors are poor. This study was conducted to examine the importance of DNA ploidy in patients with locally recurrent oral carcinoma. DNA flow cytometry was performed on 93 primary oral carcinomas and their subsequent recurrences. Eight patients with diploidy of both the primary tumor and the recurrence never developed lymph node metastasis. The 5-year overall survival rate of this group was 87%. For 80 aneuploid primary carcinomas, recurrences developed that were also aneuploid. Only 31% of these patients were 5-year survivors (P < 0.001). Lymph node metastasis at presentation was found in 55% of this group, whereas 13% of initially lymph node negative patients presented with regional disease at second surgery. Five of 13 diploid primary tumors recurred with aneuploid cell lines. Three of these five patients died, two with regional metastasis. The 5-year survival rate of patients with aneuploid recurrences who were never afflicted with lymph node involvement (41%) was better (P < 0.05) than the 5-year survival rate of those with metastasis...Continue Reading

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Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J. ScurryA. Gazdar
Apr 30, 2003·Cytometry. Part B, Clinical Cytometry·Andreas O H GerstnerFriedrich Bootz
Sep 2, 2011·Oral Oncology·Jantine F BremmerBoudewijn J M Braakhuis
Mar 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andreas O H GerstnerFriedrich Bootz
Feb 26, 1999·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·J HemmerJ Kreidler
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May 17, 2007·Mund-, Kiefer- und Gesichtschirurgie : MKG·Oliver DriemelJörg Hemmer
Sep 5, 2008·Current Protocols in Cytometry·Andreas O H Gerstner, Attila Tàrnok
Mar 21, 2012·Head and Neck Pathology·Andre W van ZylWillie F P van Heerden
Dec 27, 2016·Molecular Cytogenetics·Mathew Bloomfield, Peter Duesberg
May 1, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Walter GiarettiPatrizio Castagnola

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