The Value of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis

Gastroenterology Research and Practice
Yantian CaoFangfang Shen

Abstract

Fecal microbiota transplantation (FMT) has challenged the traditional management of ulcerative colitis (UC) in recent years, while it remained controversial. We aimed to provide a systematic protocol of FMT treatment on UC. Studies reporting on FMT treatment in UC patients were performed. A fixed-effect model was used to assess the efficacy of FMT. Eighteen studies were enrolled (n = 446). A pooled proportion of patients who received FMT had a significant efficacy compared to the placebo group (odds ratio (OR): 2.73, P = 0.002) with a low risk of heterogeneity (P = 0.59, I2 = 0%). The Mayo score decreased to 5 points in a state of mild-moderate activity after FMT treatment, and the optimal range of the Mayo score baseline was 6-9 for FMT administration. Then, the baseline of the Shannon diversity index (SDI) had a negative correlation with the clinical response rate (R = -0.992, P = 0.08) or remission rate (R = -0.998, P = 0.036), and the optimal diversity of bacteria was at 7 days to one month. Moreover, the colonoscopy delivery and unrelated fecal donor had slight superiorities of FMT treatment. FMT treatment had a higher efficacy and shorter time-point of early assessment of effectiveness on UC patients compared to tradition...Continue Reading

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Citations

Sep 4, 2019·The ISME Journal·Kaitlyn OliphantEmma Allen-Vercoe
Jan 25, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Thomas StalderVirginie Nerich
Apr 8, 2020·Experimental and Therapeutic Medicine·Hui-Ting ChenYong-Jian Zhou
Nov 4, 2020·Scandinavian Journal of Gastroenterology·Savanne HolsterJulia König
Jun 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica GulatiLipika Chandwani

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Software Mentioned

Stata
Review Manager
SPSS
GraphPad Prism
FMT

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Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.