Abstract
To establish the accuracy of follow-up fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and the impact of FDG PET/CT result on management decisions and patient outcome prediction (overall and progression free survival) in human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC). We included 96 HPV-positive oropharyngeal SCC (OPSCC) patients with 254 follow-up PET/CT scans in the study. The PET/CT result accuracy was established with histopathology or 6-month clinical follow-up as reference standard. The impact on change in management was established for each follow-up PET/CT scan. Overall survival was evaluated using Kaplan-Meier plots with a Log-rank test. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the follow-up FDG-PET/CT were 97.0%, 92.5%, 67.0%, 99.5% and 93.1%, respectively. Follow-up PET/CT results were helpful in excluding tumour in 22% (9/41) of scans performed with prior clinical suspicion of disease and identified potential disease in 9.9% (21/213) scans performed without prior clinical suspicion. There was a change in management after 12.6% (32/254) scans. In 84.3% (214/254) scans, the patients were either observed or the sa...Continue Reading
References
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J JonesM McGurk
Oct 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sophie PériéJean-Noël Talbot
Jun 6, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Keisuke EnomotoJun Hatazawa
Nov 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christiaan A KrabbeJan L Roodenburg
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Oct 13, 2010·The Laryngoscope·Vikas MehtaStimson P Schantz
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Nov 3, 2011·Journal of Cancer Research and Therapeutics·Manisha Bisht, Sampan Singh Bist
Nov 26, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R GranataL Licitra
Jan 28, 2012·JAMA : the Journal of the American Medical Association·Maura L GillisonAnil K Chaturvedi
May 24, 2012·NCHS Data Brief·Cynthia L OgdenKatherine M Flegal
Jul 4, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eric M GendenAlfio Ferlito
Oct 16, 2012·Sexually Transmitted Diseases·Zoe R EdelsteinLaura A Koutsky
Nov 21, 2012·Archives of Otolaryngology--head & Neck Surgery·Jason Y K ChanNishant Agrawal
Feb 26, 2013·International Journal of Cancer. Journal International Du Cancer·Anuj GoenkaNancy Y Lee
Mar 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria J WorshamGeorge Divine
Oct 9, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vasavi PaidpallyRathan M Subramaniam
Jan 7, 2014·Oral Oncology·Jeffrey M VainshteinAvraham Eisbruch
Jan 30, 2014·The Laryngoscope·Yekaterina KoshkarevaRobert L Ferris
Apr 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander J AntoniouRathan M Subramaniam
Jun 21, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Charles MarcusRathan M Subramaniam
Citations
Jul 23, 2016·AJR. American Journal of Roentgenology·Charles MarcusRathan M Subramaniam
Jan 19, 2017·Nuclear Medicine Communications·Mehdi TaghipourRathan M Subramaniam
Feb 15, 2017·Clinical Nuclear Medicine·Esther MenaRathan M Subramaniam
Jul 22, 2017·AJR. American Journal of Roentgenology·Reema GoelRathan M Subramaniam
Nov 6, 2018·Clinical Nuclear Medicine·Yasemin SanliRathan M Subramaniam
Mar 6, 2019·AJR. American Journal of Roentgenology·Helena YouRathan M Subramaniam
Oct 28, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Louise Madeleine RisørJeppe Friborg
Apr 26, 2016·Nuclear Medicine Communications·Mehdi TaghipourRathan M Subramaniam
Mar 19, 2016·Nuclear Medicine Communications·Mehdi TaghipourRathan M Subramaniam
Aug 31, 2021·Seminars in Radiation Oncology·Travis C SalzilloClifton D Fuller