PMID: 8601568Jan 1, 1996Paper

The value of immunohistochemistry in patients with poorly differentiated adenocarcinomas and undifferentiated carcinomas of unknown primary

Journal of Cancer Research and Clinical Oncology
A van der GaastS C Henzen-Logmans

Abstract

A subgroup of patients with metastatic carcinomas of unknown origin may benefit from combination chemotherapy. The relevance of immunohistochemistry in detecting such patients was investigated. Immunohistochemical studies with a panel of antibodies were performed on the tissue specimens of 41 patients having a light-microscopic diagnosis of poorly differentiated adenocarcinoma or undifferentiated carcinoma of unknown origin, who had been treated with cisplatin- containing chemotherapy. The study aimed to answer the following questions: (a) Can the tissue type of the tumor be verified? (b) Can a primary organ site be identified? (c) Can a prognostic immunohistochemical profile be recognized? The original diagnosis had to be changed in 2 of the 41 patients, who turned out to have a malignant lymphoma and neuroblastoma, respectively. The primary site was diagnosed in a patient with prostate cancer, whereas in one case the diagnosis could be narrowed down to a neuroendocrine tumor. No certain immunohistochemical profile with prognostic significance could be identified. It was concluded that immunohistochemistry should be routinely used in cases of undifferentiated carcinoma of unknown primary origin to verify the histological diagn...Continue Reading

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Citations

Apr 2, 2003·Urology·Douglas ScherrUNKNOWN National Comprehensive Cancer Network
Jan 5, 2002·Journal of the American College of Surgeons·M I ChorostB C Ghosh
Nov 24, 2011·Prostate Cancer·P FurtadoF Tavora
Jul 16, 2003·The American Journal of the Medical Sciences·Jonathan E Dowell
Aug 31, 2004·Journal of Surgical Oncology·Mitchell I ChorostBimal C Ghosh
Jan 31, 2009·Seminars in Oncology·F Anthony Greco, Nicholas Pavlidis
May 14, 2005·Critical Reviews in Oncology/hematology·Nicholas Pavlidis, Karim Fizazi

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