The value of MR imaging in monitoring the effect of chemotherapy on bone sarcomas

AJR. American Journal of Roentgenology
H C HolscherJ Hermans

Abstract

We studied the value of MR imaging in monitoring the response of Ewing sarcoma and osteosarcoma to chemotherapy. Relative signal-intensity changes on MR images in the course of chemotherapy were compared with changes in tumor volume and histopathologic findings. MR scans (T1- and T2-weighted spin-echo images) were obtained in 20 patients with bone sarcoma. The first MR scan was obtained before the administration of chemotherapy in all patients. The follow-up scan was obtained in the course of treatment, before surgery. Tumor-volume and signal-intensity measurements of the intra- and extraosseous components of the tumor were analyzed. In 17 patients, histopathologic findings of the resected tumor were available for comparison with the MR images. In 12 of 17 patients there was complete agreement between changes in tumor volume, changes in the signal intensity of the extraosseous tumor component on T2-weighted images, and histopathology. In another four cases, changes in signal intensity correlated either with histopathology or with changes in tumor volume. In one patient with a pathologic fracture, no such correlation existed. A significant correlation was found between changes in signal intensities and pathologic response (r = ....Continue Reading

Citations

Jan 1, 1994·Pediatric Radiology·J C GeorgeR R Smith
May 12, 2007·Skeletal Radiology·Sinchun Hwang, David M Panicek
May 31, 2007·Journal of Cancer Research and Clinical Oncology·Yukio KawakamiToshifumi Ozaki
Aug 1, 1995·Critical Reviews in Oncology/hematology·V H Bramwell
Aug 19, 1999·Critical Reviews in Oncology/hematology·W C Peh
Mar 22, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Byung Hyun ByunSang Moo Lim
May 1, 1994·Skeletal Radiology·H M KroonA H Taminiau
Jan 1, 1993·Medical and Pediatric Oncology·M TanabeH Yoshida
Jan 11, 2012·Ultrasound in Medicine & Biology·Yen-Huai LinCheng-Yen Chang
Jul 27, 2006·Journal of Vascular and Interventional Radiology : JVIR·Jie DengAndrew C Larson
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B J Manaster
Nov 1, 1994·European Journal of Radiology·W R ReinusT Vietti
Oct 3, 1999·Journal of Magnetic Resonance Imaging : JMRI·W E ReddickB D Fletcher
Sep 21, 2007·Journal of Clinical Gastroenterology·Laura M KulikRiad Salem
Oct 28, 1998·Clinical Nuclear Medicine·S WakasugiT Masaoka
Jul 25, 2000·Clinical Orthopaedics and Related Research·K H ShinW I Yang
Aug 30, 2008·Journal of Orthopaedic Surgery·I MunajatW I Wan Faisham
Apr 1, 1998·Clinical Orthopaedics and Related Research·H J van der WoudeT L Pope
May 1, 1995·Medical and Pediatric Oncology·M TanabeK Kawamura
Aug 11, 1998·The Journal of Bone and Joint Surgery. American Volume·J S WunderJ H Healey
Jan 1, 1992·Current Problems in Diagnostic Radiology·J M BoorsteinJ S Suh
Aug 12, 2000·Seminars in Roentgenology·J C Leung, M K Dalinka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.