The value of neutrophil to lymphocyte ratio and gamma-glutamyl transpeptidase to platelet ratio in patients with hepatocellular carcinoma

Medicine
Zuojian HuShan Li

Abstract

Our study aimed to evaluate the value of neutrophil to lymphocyte ratio (NLR) and gamma-glutamyl transpeptidase to platelet ratio (GPR) in patients with hepatocellular carcinoma (HCC).A total of 565 patients with pathological diagnosis of HCC were retrospectively analyzed and 414 patients diagnosed with cirrhosis were treated as a control group. All clinical materials were collected from the First Affiliated Hospital of Guangxi Medical University.The preintervention NLR, GPR, and α-fetoprotein (AFP) were significantly higher in HCC patients than in the controls (PNLR < .000, PGPR < .000, PAFP < .000). The NLR and GPR were correlated with the Barcelona clinic liver cancer (BCLC) stages, Child-Pugh grades, and tumor size, but not with Edmondson-Steiner grades. Combined use of NLR or GPR with AFP produced larger area under the curve (AUC) (AUCNLR+AFP = 0.916; AUCNLR+AFP = 0.953) than NLR (P < .000), GPR (P < .000), or AFP (P < .000) used alone.The preintervention hematologic parameters (NLR and GPR) studied herein were associated with the BCLC stages of HCC. Combined use of NLR or GPR with AFP may improve early detection and diagnosis of HCC.

References

Jun 29, 2012·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Rafael Gómez-RodríguezJuan José Sánchez-Ruano
Aug 1, 2012·Seminars in Oncology·Gaetano BertinoGiuseppe Stefano Calvagno
May 14, 2014·Advances in Experimental Medicine and Biology·Anupam Bishayee
May 24, 2014·The Cancer Journal·Ralph FrancesconeSergei I Grivennikov
Aug 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Basile NjeiJoseph K Lim
Sep 11, 2014·World Journal of Gastroenterology : WJG·Mirko TarocchiAndrea Galli
Oct 5, 2014·The Lancet Oncology·Connie I DiakosStephen J Clarke
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fei TianYun-He Liu
Jan 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Samet ÖzerOsman Demir
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 1, 2015·Journal of Vascular and Interventional Radiology : JVIR·Daniel C SukatoAllan Tsung
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jul 5, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Samia RekikJean-Charles Nault
Aug 16, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Medine KaraFevzi Sefa Dereköy
Nov 20, 2016·Journal of Gastroenterology and Hepatology·Yong Eun ParkSeung Up Kim
Nov 11, 2017·British Journal of Cancer·Jane MargettsHelen L Reeves
Jul 20, 2018·Cancer Management and Research·Hongda ChenMin Dai

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Citations

Jul 4, 2020·Journal of Gastrointestinal Cancer·Ramazan DertliHuseyin Ataseven
Sep 22, 2020·World Journal of Gastroenterology : WJG·Ayman Bannaga, Ramesh P Arasaradnam
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
GraphPad Prism

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