The value of oxybutynin in transdermal patches for treating overactive bladder

Actas urologicas españolas
J Salinas-CasadoJ Galván

Abstract

There is currently a broad therapeutic arsenal of drugs for treating overactive bladder syndrome (OAB). However, there is still a need for new compounds and for improving known drugs in terms of efficacy, compliance and tolerability. To report the scientific evidence on the safety and efficacy of transdermal oxybutynin (OXY-TDS) for treating OAB. A systematic review without time restrictions was conducted until May 2015 in the MEDLINE/PubMed database. We also performed a manual review of abstracts published in international urogynaecology congresses. The evaluated studies show that patients treated with OXY-TDS experience a significant reduction in urinary incontinence episodes compared with placebo, which is comparable to that observed in patients treated with oral oxybutynin or with tolterodine. In all of the studies, we observed improvements in symptoms from the second or third week of treatment and in a sustained manner until the end of treatment (6, 12 or 24 weeks). The clinical practice study also showed improved quality of life, achieving benefits in numerous patient profiles, with an efficacy independent of previous treatments. The safety of the drug was demonstrated in the various patient profiles. OXY-TDS represents a...Continue Reading

References

Jul 20, 2002·The Journal of Urology·Roger R DmochowskiUNKNOWN Transdermal Oxybutynin Study Group
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Mar 20, 2015·Drug Delivery and Translational Research·Achyut Khire, Pradeep Vavia
Sep 1, 2015·Current Oncology Reports·Eleonora Teplinsky, Francisco J Esteva

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Citations

Jan 28, 2016·Current Opinion in Urology·Calvin LeeMargot S Damaser
May 1, 2021·Pharmaceuticals·Zara KhizerMuhammad Usman Ghori

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