PMID: 9542745May 30, 1998Paper

The value of PCNA and AgNOR staining in endoscopic biopsies of gastric mucosa

Pathology, Research and Practice
S P IrazustaM Trevisan

Abstract

The aim of the present study was to examine the usefulness of the quantification of PC10-positive-cells and of Argyrophilic Nucleolar Organizer Regions (AgNORs) in gastric biopsies for the identification of gastric mucosal proliferative lesions. Fifty seven paraffin-embedded endoscopic biopsies were classified into four histologic groups: normal, inflammatory, dysplastic and neoplastic mucosa. The percentage of PC10-positive cells was determined by immunohistochemistry. The AgNOR parameters determined included the total number of all identifiable silver precipitations in the nucleus, the mean number of silver precipitations per cluster, and the presence of morphologically heterogenous silver precipitations. Group comparisons were performed using the Kruskall Wallis and Dunn non-parametric tests with a significance level of 5%. A discriminant analysis (followed by the jack-knife procedure) was performed using the three AgNOR parameters plus the percentage of PCNA-positive cells as the independent variables and histological groups as the dependent variable. All three AgNOR parameters, as well as the percentage of PCNA-stained nuclei, showed their highest values in the carcinoma group. However, no good differentiation among the fo...Continue Reading

References

Aug 1, 1991·Journal of Clinical Pathology·S JainD A Levison
Jan 1, 1990·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·N WilkinsonH Fox
Apr 2, 1987·Nature·R BravoH Macdonald-Bravo
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M DerenziniV Eusebi
Mar 1, 1980·The Journal of Cell Biology·R Bravo, J E Celis
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·F HofstädterJ Rüschoff
Jul 17, 1995·International Journal of Cancer. Journal International Du Cancer·C MiraccoP Tosi
Oct 1, 1993·Diagnostic Cytopathology·M S TrevisanL A Magna
Jan 1, 1993·Acta Haematologica·K Metze, I G Lorand-Metze
Nov 1, 1995·Pathology International·L Z XuG Chen
May 1, 1996·Digestive Diseases and Sciences·J E Nishizawa-TakanoY Tagawa
Jan 1, 1996·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J RüschoffJ Schlegel
Dec 1, 1996·Clinical Molecular Pathology·I Lorand-Metze, K Metze

❮ Previous
Next ❯

Citations

Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C TuccilloM Romano
Aug 23, 2012·BMC Complementary and Alternative Medicine·Rahmat Ali Khan
Aug 21, 2007·Acta histochemica·Debora Barreto TeresaChristiane Pienna Soares
May 20, 2008·Veterinary Pathology·E M P AlmeidaM L Cintra
Mar 9, 1999·Cytopathology : Official Journal of the British Society for Clinical Cytology·E M CiaK Metze
Aug 4, 2004·Journal of Oral Science·Elena Riet Correa RiveroMaria Cassia Ferreira de Aguiar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Related Papers

Micron : the International Research and Review Journal for Microscopy
L C SpolidorioO P Almeida
Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Vengai MavangiraDae Young Kim
Journal of Comparative Pathology
R O RamadanM H Taj el Deen
© 2022 Meta ULC. All rights reserved