The value of positron emission tomography in the surgical management of recurrent papillary thyroid carcinoma.

World Journal of Surgery
C S GrantIan D Hay

Abstract

Patients with papillary thyroid carcinoma (PTC) may suffer recurrence despite thyroidectomy and complete radioiodine (RAI) ablation. Reoperation is vitally dependent on accurate and complete disease localization, typically utilizing cervical ultrasonography (US) and/or computed tomography. Our aim was to determine the comparative value of F18-fluorodeoxyglucose positron emission tomography (PET) to US for localization of locoregional recurrence in patients who underwent reoperation for recurrent PTC. From 1999 to 2004, 30 patients who underwent re-exploration and 100 nonoperated patients who were investigated with PET for possible recurrent PTC were reviewed. The surgical group [9 males, 21 females; mean age=50 years (range=18-84 years)] all had received RAI ablation. Preoperative thyroid-stimulating hormone (TSH), thyroglobulin (Tg), and location of metastasis were recorded for each imaging study and surgical exploration. All separate sites that contained disease pathologically must have been identified by imaging for a patient to be considered true positive (TP). PET scans were TP in 43%, false positive in 7%, false negative (FN) in 50%, and had a sensitivity of 46%. Comparable US results were 86%, 10%, 3%, and 96%. Of the 15...Continue Reading

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Citations

Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Sippel, Herbert Chen
Dec 28, 2010·The Surgical Clinics of North America·Bianca J Vazquez, Melanie L Richards
Feb 24, 2011·ANZ Journal of Surgery·Ivan Ho ShonPeter Campbell
Jan 30, 2015·Thyroid : Official Journal of the American Thyroid Association·Linda ChamiJean Paul Travagli
Apr 23, 2019·Molecular and Clinical Oncology·Francesco SopraniMaurizio Puccetti

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