The value of prolactin in predicting prolactinοma in hyperprolactinaemic polycystic ovarian syndrome

European Journal of Clinical Investigation
Eleni Magdalini KyritsiHarpal S Randeva

Abstract

To identify a serum prolactin (PRL) cut-off value indicative of a PRL-producing adenoma in women with polycystic ovarian syndrome (PCOS) and hyperprolactinaemia and characterize such patients. In the present retrospective case-control study, the medical records of 528 PCOS women were reviewed. Pituitary magnetic resonance imaging (MRI) was performed in PCOS patients with PRL levels ≥94.0 ng/mL and/or symptoms suspicious of a pituitary adenoma (PA). Prolactinoma diagnosis was made in the presence of an MRI-identifiable PA with biochemical and radiological response to dopamine agonists. Receiver operating characteristic (ROC) curve analysis was performed to determine a serum PRL threshold that could identify hyperprolactinaemic PCOS subjects with prolactinomas. Clinical, metabolic and endocrine parameters were also analysed. Among 528 patients with PCOS, 60 (11.4%) had elevated PRL levels. Of 44 (73.3%) patients who had pituitary imaging, 19 had PAs, 18 normal MRI and 7 other abnormalities. Patients harbouring prolactinomas had significantly higher PRL levels compared to patients without adenomas (median PRL 95.4 vs 49.2 ng/mL, P < .0001). A PRL threshold of 85.2 ng/mL could distinguish patients with prolactinomas with 77% sensit...Continue Reading

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Sep 25, 2016·Clinical Endocrinology·Eleni Magdalini KyritsiHarpal S Randeva

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Citations

Dec 19, 2019·Journal of Clinical Medicine·Irene SamperiNiki Karavitaki
Sep 17, 2019·Clinical Medicine Insights. Reproductive Health·Clémence DelcourDidier Dewailly
Jul 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Philippe Chanson, Dominique Maiter

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