The value of prospective monitoring of Epstein-Barr virus DNA in blood samples of pediatric liver transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
R ScheenstraH J Verkade

Abstract

Post-transplant lymphoproliferative disease (PTLD) is one of the major causes of morbidity and mortality in transplantation patients. A primary Epstein-Barr virus (EBV) infection is a major risk factor for developing PTLD. The aim of this study was to determine circulating EBV DNA after liver transplantation in pediatric patients in relation to primary EBV infection and development of PTLD. EBV serology was performed before transplantation. Every 4 weeks after transplantation a competitive quantitative polymerase chain reaction (PCR) assay for EBV nuclear antigen-1 was performed in 13 patients. Patients were followed for development of a PTLD. Before transplantation four patients were EBV seropositive and nine patients were EBV seronegative. In one of the four patients who were EBV seropositive before transplantation, EBV DNA became detectable after transplantation, with a peak load of 3600 copies/mL. None of these four patients developed a PTLD. Eight of the nine patients who were EBV seronegative before transplantation developed positive EBV DNA samples. EBV DNA was first detected at a mean of 64 days after transplantation (range 38-89). The mean peak EBV DNA load was 79,700 copies/mL (3600-446,000). Two of these patients dev...Continue Reading

Citations

Aug 12, 2009·International Journal of Hematology·Hideaki OhtaKeiichi Ozono
Dec 17, 2008·Digestive Diseases and Sciences·Sharad SharmaNicolas Jabbour
Jan 12, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Stephan SchubertPetra Reinke
May 10, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C Kullberg-LindhM Lindh
Jul 29, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D D HenryV R Dharnidharka
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Loreto HierroPaloma Jara
Oct 21, 2011·Journal of Medical Virology·Beata KasztelewiczKatarzyna Dzierżanowska-Fangrat
Jun 22, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·B KasztelewiczK Dzierżanowska-Fangrat
Aug 26, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Raisa LoginovIrmeli Lautenschlager
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian BendenMartin J Elliott
Jun 28, 2005·Critical Reviews in Oncology/hematology·Anna L TaylorJ Andrew Bradley
Dec 1, 2011·Therapeutic Advances in Hematology·Heiner Zimmermann, Ralf Ulrich Trappe
Jun 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Krzysztof MuchaLeszek Paczek
Dec 5, 2006·Expert Review of Anti-infective Therapy·Kimberly Hanson, Barbara Alexander
Jul 11, 2008·The Oncologist·S Yousuf ZafarJon P Gockerman

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