PMID: 3632162Sep 1, 1987Paper

The value of serum magnesium determination in hypertensive patients receiving diuretics

Archives of Internal Medicine
K KroenkeJ F Hanley

Abstract

Some clinicians contend that hypomagnesemia is a common problem in patients receiving diuretic therapy and that routine serum magnesium determinations may be indicated in such patients. We determined serum magnesium (Mg++) levels in 354 patients with uncomplicated hypertension. No significant difference was observed in the mean Mg++ between the 245 diuretic-treated patients and the 109 patients not receiving diuretics, 0.965 vs 0.97 mmol/L (1.93 vs 1.94 mEq/L). When analyzed by type of diuretic, there were statistically significant differences in the mean serum Mg++ concentrations between those receiving thiazides, 0.94 mmol/L (1.87 mEq/L); those receiving no diuretics, 0.97 mmol/L (1.94 mEq/L); and those receiving triamterene-containing diuretics, 1.01 mmol/L (2.01 mEq/L). These absolute differences, however, were clinically quite small, and hypomagnesemia was uncommon. Neither patient age, the duration of diuretic use, nor the serum potassium level correlated with Mg++. With respect to dose, those receiving 100 mg/d of hydrochlorothiazide had the lowest Mg++ concentrations and the greatest prevalence of hypomagnesemia (12%), defined as Mg++ less than 0.75 mmol/L (1.5 mEq/L). Serum Mg++ need not routinely be determined in pati...Continue Reading

Citations

Jul 1, 1993·British Journal of Clinical Pharmacology·D L Davies, R Fraser
Jan 26, 2010·Expert Opinion on Drug Safety·Pantelis A SarafidisAnastasios N Lasaridis
Jul 8, 2000·Kidney International·J M Arthur, S Shamim
Nov 14, 1997·Kidney International·G A Quamme
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jacob Atsmon, Eran Dolev
Mar 10, 2017·American Journal of Physiology. Renal Physiology·R Todd Alexander, Henrik Dimke

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