The Value of Serum MicroRNA Expression Signature in Predicting Refractoriness to Bortezomib-Based Therapy in Multiple Myeloma Patients.

Cancers
Paweł RobakTadeusz Robak

Abstract

Bortezomib is the first-in-class proteasome inhibitor, commonly used in the treatment of multiple myeloma (MM). The mechanisms underlying acquired bortezomib resistance in MM are poorly understood. Several cell-free miRNAs have been found to be aberrantly regulated in MM patients. The aim of this pilot study was to identify a blood-based miRNA signature that predicts bortezomib-based therapy efficacy in MM patients. Thirty MM patients treated with bortezomib-based regimens were studied, including 19 with refractory disease and 11 who were bortezomib sensitive. Serum miRNA expression patterns were identified with miRCURY LNA miRNA miRNome PCR Panels I+II (Exiqon/Qiagen). Univariate analysis found a total of 21 miRNAs to be differentially expressed in patients with MM according to bortezomib sensitivity. Multivariate logistic regression was created and allowed us to discriminate refractory from sensitive patients with a very high AUC of 0.95 (95%CI: 0.84-1.00); sensitivity, specificity and accuracy were estimated as 0.95, 0.91, and 0.93. The model used expression of 3 miRNAs: miR-215-5p, miR-181a-5p and miR-376c-3p. This study is the first to demonstrate that serum expression of several miRNAs differs between patients who are bor...Continue Reading

References

Jul 27, 2001·Journal of Clinical Epidemiology·E W SteyerbergJ D Habbema
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Jul 21, 2006·Leukemia·B G M DurieUNKNOWN International Myeloma Working Group
Jul 25, 2007·Nature Reviews. Cancer·Teru HideshimaKenneth C Anderson
Nov 2, 2007·Leukemia·K C AndersonUNKNOWN ASH/FDA Panel on Clinical Endpoints in Multiple Myeloma
Apr 30, 2009·Blood·Aldo M RoccaroIrene M Ghobrial
Mar 18, 2011·The New England Journal of Medicine·Antonio Palumbo, Kenneth Anderson
Oct 7, 2011·Journal of the National Comprehensive Cancer Network : JNCCN·Jacob P LaubachPaul G Richardson
Apr 13, 2012·Nature Reviews. Cancer·Gareth J MorganFaith E Davies
Nov 1, 2012·Biochemical and Biophysical Research Communications·Dehui XuEls Van Valckenborgh
Mar 13, 2013·Oncotarget·Maria Teresa Di MartinoPierfrancesco Tassone
Nov 26, 2014·Nature Reviews. Clinical Oncology·Meletios A DimopoulosKenneth C Anderson
Jun 4, 2015·Oncotarget·Manuela FerracinMassimo Negrini
Nov 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Annamaria GullàPierfrancesco Tassone
Jul 9, 2016·Journal of Cancer·Yue LiXiaoning Peng
Aug 6, 2016·Oncotarget·Jahangir AbdiHong Chang
Dec 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Teng HuangXia He
Mar 11, 2017·Cancer Management and Research·Meera MohanFaith E Davies
Jun 19, 2017·Journal of Hematology & Oncology·Nasrin RastgooHong Chang
Oct 19, 2017·International Journal of Molecular Medicine·Li-Li FangHeng Luo
Jun 8, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi LiuXiefu Zhang
Jul 22, 2018·Leukemia·Santiago BarrioK Martin Kortüm
Aug 31, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sandra Amalie DybosHaakon Skogseth
Sep 25, 2018·Cancer Treatment Reviews·Pawel RobakTadeusz Robak
Dec 12, 2018·International Journal of Molecular Medicine·Faqing TianJian Jiang

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Methods Mentioned

BETA
xenografts
PCR

Software Mentioned

IPA
BestKeeper
R
Statistica
geNorm
miRNAselector R package
NormFinder
Ingenuity Pathway Analysis
NormiRazor

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