The value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection.

Clinical and Experimental Immunology
G K ChinE R Kaminski

Abstract

Acute rejection remains a poor predictor of graft outcome. In this study, we measured serum levels of interferon (IFN)-gamma and neopterin by enzyme-linked immunosorbent assay and a single nucleotide polymorphism (SNP) within the 3' untranslated region of the interleukin (IL)-12 B gene (1188 A/C) to determine whether either of these factors could predict acute rejection in renal transplantation. Significantly higher early post-transplant neopterin levels (days 5-7; 35.7 versus 19.9 nmol/l) were observed in recipients who subsequently rejected their grafts. Post-transplant neopterin levels showed a strong positive correlation with 1-month creatinine levels (Spearman's correlation 0.62, P < 0.001), suggesting macrophage activation early after transplantation. Pretransplant neopterin and IFN-gamma levels and the IL-12B gene SNP did not predict acute rejection in this small retrospective study. The ability to predict acute rejection non-invasively early after transplantation could lead to individual tailoring of immunosuppressive regimens and perhaps lead eventually to longer graft survival.

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Citations

Aug 19, 2010·Cancer Immunology, Immunotherapy : CII·Alain G ZeimetChristian Marth
May 20, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G TarantinoA Riccio
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Jul 25, 2009·Free Radical Biology & Medicine·Jeannette Vásquez-Vivar
Mar 27, 2010·Hemodialysis International·Ali AsciGonul Sahin
Jan 1, 2014·Clinical Transplantation·Hege PihlstrømHallvard Holdaaas
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Jul 15, 2015·Clinical Biochemistry·Jana StojanovaNicolas Picard
Jul 7, 2016·Mediators of Inflammation·Dorota KamińskaMarian Klinger
Apr 2, 2009·Current Opinion in Organ Transplantation

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