The value of ultrahigh resolution OCT in dermatology - delineating the dermo-epidermal junction, capillaries in the dermal papillae and vellus hairs

Biomedical Optics Express
Niels Møller IsraelsenOle Bang

Abstract

Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised of the lower surface of a single cell layer in epidermis (the stratum basale) connected to an even thinner membrane (the basement membrane). The basement membrane is attached to the underlying dermis. In this work we investigate the impact of an improved axial and lateral resolution on the applicability of OCT for imaging of the skin. To this goal, OCT images are compared produced by a commercial OCT system (Vivosight from Michaelson Diagnostics) and by an in-house built ultrahigh resolution (UHR-) OCT system for dermatology. In 11 healthy volunteers, we investigate the DEJ signal characteristics. We perform a detai...Continue Reading

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References

Nov 22, 1991·Science·D HuangC A Puliafito
Sep 1, 1995·Nature Medicine·J G FujimotoE A Swanson
Jan 7, 1998·Journal of the American Academy of Dermatology·J WelzelR Engelhardt
Aug 31, 1999·Lancet·H C Nousari, G J Anhalt
Jan 9, 2001·The Journal of Investigative Dermatology. Symposium Proceedings·I M Braverman
Jul 28, 2007·The Journal of Investigative Dermatology·Giovanni PellacaniScott Menzies
Mar 1, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·Mette MogensenGregor B E Jemec
Apr 29, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mette MogensenGregor B E Jemec
Oct 17, 2009·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·J HegyiC Berking
Apr 15, 1994·Optics Letters·J A IzattJ G Fujimoto
May 10, 2011·Investigative Ophthalmology & Visual Science·Michaël J A GirardJean Martial Mari
Aug 4, 2012·Applied Optics·Ali Hojjatoleslami, Mohammad R N Avanaki
Oct 20, 2012·Biomedical Optics Express·Cedric BlatterRainer A Leitgeb
Dec 12, 2012·Journal of Biomedical Optics·Rami ArchidJuergen Lademann
Jul 9, 2013·Archives of Dermatological Research·Marc A L M BooneV Del Marmol
Jan 28, 2014·Biomedical Optics Express·Miao ZhangPing Yu
Apr 3, 2014·Journal of the American Academy of Dermatology·Jo-David FineGiovanna Zambruno
Jul 31, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·T GambichlerT Maier
Aug 27, 2014·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·K MizukoshiK Takahashi
Sep 4, 2014·The Journal of Investigative Dermatology·Sila KurugolMilind Rajadhyaksha
Sep 17, 2014·Archives of Dermatological Research·Alia Arif HussainGregor Borut Ernst Jemec
Sep 23, 2014·Journal of Biophotonics·Thilo GambichlerTanja Maier
Feb 7, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·M A L M BooneV Del Marmol
Jun 13, 2015·Archives of Dermatological Research·M A L M BooneV Del Marmol
Jan 26, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S SchuhJ Welzel
Feb 27, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·S SchuhJ Welzel
Sep 24, 2016·Applied Optics·Catherine ChinAdrian Podoleanu
Apr 18, 2017·Applied Optics·Adeleh TaghavikhalilbadMohammad R N Avanaki
Nov 16, 2017·Optics Letters·Michael MariaAdrian Podoleanu
Dec 22, 2017·Scientific Reports·Saba AdabiMohammadreza Nasiriavanaki

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Citations

Jan 21, 2020·Lasers in Surgery and Medicine·Mikaela KislevitzJeffrey Kenkel
Jan 25, 2019·Light, Science & Applications·Niels M IsraelsenOle Bang
May 3, 2019·Optics Express·Rasmus Dybbro Engelsholm, Ole Bang
Jun 30, 2021·Light, Science & Applications·Shreesha Rao D SOle Bang
Oct 16, 2021·Journal of Cosmetic Dermatology·Shishira R JartarkarMohamad Goldust

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