The value of ventriculo-peritoneal shunting in patients with glioblastoma multiforme and ventriculomegaly

Acta neurochirurgica
J RothZ Ram

Abstract

Patients with an advanced-stage glioblastoma multiforme (GBM) often show general motor, gait, and cognitive deterioration. Some have radiological evidence of ventriculomegaly, but the relevance of this to their symptoms may be unclear. Distinction between tumour patients who have dilated fluid spaces as a consequence of tissue loss from surgery or treatment, and those who have a symptomatic hydrocephalic process, one who may gain benefit from insertion of a ventriculo-peritoneal shunt, is an important clinical challenge. From a series of 530 GBM patients treated by a single surgeon (ZR), we retrospectively reviewed 16 patients with advanced-stage GBM who had presented with non-obstructive ventriculomegaly and clinical deterioration not explained by progressive disease. Each had been treated by insertion of a ventriculo- peritoneal shunt (VPS). Assessments included clinical features, Karnofsky Performance Scale, motor and cognitive findings, complications and survival. Ten patients benefited from insertion of the shunt, with moderate to significant cognitive improvement. Of seven patients who presented with motor symptoms, such as gait instability, general weakness, and slowness, four patients showed significant motor improvemen...Continue Reading

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Citations

Sep 13, 2011·Journal of Neurosurgery·Nicola MontanoRoberto Pallini
Apr 16, 2014·Clinical Neurology and Neurosurgery·Claudia M FischerChristoph M Woernle
Aug 30, 2012·Acta neurochirurgica·Sonia Tejada-SolísRicardo Díez-Valle
Oct 31, 2014·Annals of Clinical and Translational Neurology·Macarena I de la Fuente, Lisa M DeAngelis
Nov 5, 2016·Journal of Neurosurgery·Jessin K JohnIan Y Lee
Nov 22, 2017·British Journal of Neurosurgery·Thomas BeezMichael Sabel
Dec 23, 2017·Journal of Neurosurgery·Lorenzo RinaldoIan F Parney
Jul 27, 2018·PloS One·Taylla Klei Felix SouzaLionel Fernel Gamarra
Nov 28, 2019·Surgical Neurology International·Juan F VillalongaFrancisco Marcó Del Pont
Jun 5, 2018·Fluids and Barriers of the CNS·Bujung HongJoachim K Krauss
Jul 4, 2017·Neurosurgical Review·Sayied Abdol Mohieb HosaineyTorstein R Meling
Aug 19, 2018·Neurosurgical Review·Sayied Abdol Mohieb HosaineyTorstein R Meling

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