The Values and Limitations of FDG-PET/CT for Diagnosis of Hibernoma

Case Reports in Orthopedics
Jong Hoon ParkAkira Kawai

Abstract

Hibernoma is a rare benign lipogenic tumor of brown fat that develops in a wide variety of locations. Although the features of hibernoma demonstrated by MRI resemble those of liposarcoma, recent FDG-PET/CT studies have documented higher radiotracer uptake than liposarcoma, suggesting that FDG/PET/CT is useful for differentiating hibernoma from liposarcoma. Here we report two cases of hibernoma that showed relatively lower SUVs than those reported previously, lying within the range for liposarcoma. Our findings emphasize that hibernoma needs to be included in the differential diagnosis of any fat-containing tumor showing intense accumulation by FDG-PET/CT. Although it is unlikely that such a rare condition could be reasonably diagnosed on the basis of MRI and FDG-PET/CT alone due to possible SUV overlap between hibernoma and liposarcoma, it is important to recognize this extremely rare lipogenic tumor for accurate diagnosis and appropriate management.

References

Jul 1, 1996·Skeletal Radiology·G AlvineM Huntrakoon
Aug 1, 1997·Skeletal Radiology·S PeerW Judmaier
Jun 8, 2001·The American Journal of Surgical Pathology·M A FurlongM Miettinen
Oct 31, 2001·Skeletal Radiology·S E AndersonL S Steinbach
Apr 16, 2002·Clinical Nuclear Medicine·Barry E ChattertonPenelope Cohen
May 28, 2003·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Jun AokiKenji Takagishi
May 25, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·David LinJoseph Mantil
Dec 6, 2005·Skeletal Radiology·Jane ColvilleDavid M Panicek
Dec 8, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Carlos A GarciaM Majd
Apr 22, 2006·Journal of Computer Assisted Tomography·Takashi TsuchiyaToshihiko Ogino
Jun 5, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Rathan M SubramaniamDouglas A Collins
Oct 2, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M J BurdickD A Henry

❮ Previous
Next ❯

Citations

Oct 26, 2018·Melanoma Research·Joaquim MarcovalRosa Fornons-Servent
Aug 14, 2020·Curēus·Jason M ZhaoRyan Schwope

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.