The variability of skin test hypersensitivity reactions in cystic fibrosis and asthma

Clinical Allergy
J O Warner

Abstract

Cystic fibrosis (CF) children had a greater variability of skin prick test response compared with asthmatic children, when the tests were performed on two occasions. This suggests that there is a different cause for the allergy in the two groups, perhaps because the asthmatics have a transient period of susceptibility to sensitization in infancy and the CF children a persistent vulnerability. Amongst the asthmatic children, clinical improvement was associated with loss of some skin prick test reactions, and clinical deterioration with an increase in the number of positive reactions. Thus continuing allergic reactions may maintain a mucosal defect, resulting in a persistence of susceptibility to allergen sensitization, and control of the reactions may re-establish normal mucosal defence mechanisms.

References

Dec 1, 1976·Archives of Disease in Childhood·J O Warner
Sep 1, 1975·Clinical Allergy·J D AllanH McFarlane
Jul 1, 1976·Archives of Disease in Childhood·J O WarnerJ F Soothill
Dec 1, 1973·Clinical Allergy·J F Soothill

Citations

Jan 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·J O Warner, S A Kilburn
Jun 1, 1981·Archives of Disease in Childhood·F J HolzerP D Phelan
Dec 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J O Warner
Aug 3, 2010·Allergologia et immunopathologia·J AntunesJ Cavaco
Jan 1, 1982·Clinical Allergy·C W ClarkeJ Pepys

Related Concepts

Asthma
Pulmonary Cystic Fibrosis
Immediate Hypersensitivity
Hypersensitivity Skin Testing

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