The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test

Biometrics
J J Chen, Glenys Thomson

Abstract

It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.

References

Feb 1, 1988·Idengaku zasshi·M Kimura
May 1, 1986·Annals of Human Genetics·C A Smith

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Citations

Apr 16, 2009·European Journal of Human Genetics : EJHG·Jin J ZhouJanet S Sinsheimer
Aug 27, 2013·Biostatistics·Rachel Ward, Raymond J Carroll
Jun 6, 2009·Annals of Human Genetics·Dewei SheZhaohai Li
May 25, 2005·Genetics·John J ChenGlenys Thomson
Jul 1, 2009·Genetics and Molecular Biology·Marcelo S LaurettoJulio M Stern
Apr 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ammarin ThakkinstianJohn Attia
Mar 30, 2020·HLA : Immune Response Genetics·Shiho HashimotoMasahiro Satake
Feb 3, 2019·Diabetes Research and Clinical Practice·Asher FawwadJanelle Annette Noble
Apr 11, 2021·Pediatric Diabetes·Tomader Ali Mohammed IbrahimGraham David Ogle

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