The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders

Brain and Behavior
Sean KristjanssonE C Nelson

Abstract

Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations. We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance. CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly ...Continue Reading

References

Jul 1, 1989·Paediatric and Perinatal Epidemiology·D M FergussonJ M Lawton
Dec 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·P E MullenG P Herbison
Oct 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·D M FergussonL J Horwood
Oct 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·D M FergussonM T Lynskey
Jul 1, 1997·Child Abuse & Neglect·D M Fergusson, M T Lynskey
Sep 23, 1997·Psychological Medicine·R C KesslerK S Kendler
May 10, 2001·American Journal of Public Health·B E MolnarR C Kessler
Oct 23, 2001·Twin Research : the Official Journal of the International Society for Twin Studies·A C HeathN G Martin
Mar 5, 2003·Child Abuse & Neglect·David P BernsteinWilliam Zule
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jochen Hardt, Michael Rutter
Jul 21, 2006·Psychological Medicine·Elliot C NelsonNicholas G Martin
Mar 24, 2007·Alcoholism, Clinical and Experimental Research·Julia D GrantNicholas G Martin
Feb 18, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Vivia V McCutcheonNicholas G Martin
Apr 20, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Elliot C NelsonNicholas G Martin
Dec 14, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Katherine M KeyesDeborah S Hasin
Jan 4, 2012·Archives of General Psychiatry·Laura BevilacquaMary-Anne Enoch
Feb 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hans Jörgen GrabeHarald Jürgen Freyberger
Mar 7, 2012·Archives of General Psychiatry·Arpana AgrawalMichael T Lynskey
Mar 17, 2012·Alcoholism, Clinical and Experimental Research·Ming-Chyi HuangMarkus Heilig

❮ Previous
Next ❯

Citations

Aug 31, 2016·Frontiers in Genetics·Caitlin E CareyRyan Bogdan
Mar 28, 2017·Pain and Therapy·Joseph V PergolizziRobert B Raffa
Nov 8, 2017·Molecular Psychiatry·A AgrawalE C Nelson
Nov 29, 2017·International Journal of Psychiatry in Medicine·Boris KarpovErkki Isometsä
May 22, 2019·The American Journal of Drug and Alcohol Abuse·Joao P De AquinoRobert Rosenheck

❮ Previous
Next ❯

Software Mentioned

Mplus
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.