The variances in cytokine production profiles from non- or activated THP-1, Kupffer cell and human blood derived primary macrophages following exposure to either alcohol or a panel of engineered nanomaterials

PloS One
Ali KermanizadehVicki Stone

Abstract

The portfolio of cytokines is key to the function of macrophages as sentries of the innate immune system as well as being critical for the transition from innate to adaptive immunity. Cytokine bias is critical in the fate of macrophages into a continuum of inflammatory to anti-inflammatory macrophages. Due to advances in the field of toxicology, increasingly advanced multi-cellular in vitro safety assessment models are being developed in order to allow for a better predication of potential adverse effects in humans with many of these models include a macrophage population. The selection of the correct macrophage cells in these advanced in vitro models is critical for a physiologically relevant and realistic immune response. In this study we investigated cytokine response profile (IL1-β, IL6, IL10 and TNF-α) of activated and non-activated THP-1 (immortalized monocyte-like cell line), primary human Kupffer cells (liver resident macrophages) and human primary peripheral blood mononuclear cells following exposure of a panel of nanomaterials or ethanol. The data demonstrated that the THP-1 cell line are not great cytokine producers. The PBMC appear to be a good in vitro surrogate for circulating/pro-inflammatory macrophages but are ...Continue Reading

References

Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Sep 8, 2001·Mediators of Inflammation·M P DabrowskiS Szmigielski
Dec 24, 2002·Trends in Immunology·Simone MocellinFrancesco M Marincola
Sep 5, 2006·Cancer Metastasis Reviews·Frances Balkwill
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Fernando A BozzaPatrícia T Bozza
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie BenoitJean-Louis Mege
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Dec 19, 2013·Nanotoxicology·Ali KermanizadehVicki Stone
Mar 15, 2014·Molecules and Cells·Adam C LabonteYoung S Hahn
Mar 29, 2014·Clinical Orthopaedics and Related Research·D Rick SumnerEd Purdue
Jul 2, 2014·Nanotoxicology·Forrest Jessop, Andrij Holian
Oct 24, 2014·Frontiers in Immunology·Guillermo Arango Duque, Albert Descoteaux
Aug 12, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Nicklas Raun JacobsenPeter Møller
Feb 18, 2016·Cellular Microbiology·Lars FrankenChristian Kurts
Oct 22, 2016·Basic & Clinical Pharmacology & Toxicology·Ali KermanizadehSteffen Loft
Jan 4, 2017·ACS Nano·Sonya A MacParlandIan D McGilvray
Mar 21, 2017·Nature Reviews. Immunology·Oliver Krenkel, Frank Tacke
Apr 30, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ali KermanizadehPeter Møller
Apr 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rasheed AhmadEvan D Rosen
Apr 19, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shihab KochumonRasheed Ahmad
Mar 8, 2019·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Fatema Al-RashedRasheed Ahmad
Jul 10, 2019·Journal of Leukocyte Biology·Daniel I PetkovMarcelo J Kuroda

❮ Previous
Next ❯

Citations

Jul 21, 2021·Veterinary Immunology and Immunopathology·Momena KhatunChristine M Røntved
Nov 25, 2021·Expert Opinion on Drug Discovery·Bilal Zulfiqar, Vicky M Avery

❮ Previous
Next ❯

Methods Mentioned

BETA
Dynamic Light Scattering
density gradient centrifugation
Assay

Software Mentioned

Minitab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pflügers Archiv : European journal of physiology
Zeinab Abdullah, Percy A Knolle
Journal of Immunological Methods
Michael SchnoorStefan Lorkowski
© 2021 Meta ULC. All rights reserved