The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xu WangHaiyong Gu

Abstract

To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G. We performed a hospital-based case-control study to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscan(TM) kit was used to determine the genotypes. The IL1f7 rs3811047 G>A polymorphism was significantly associated with a decreased risk of GCA either in the single locus analyses or the recessive genetic model. However, there was no significant association between the other five SNPs and GCA risk. These results elucidated that the functional polymorphism, IL1f7 rs3811047 G>A, might contribute to GCA susceptibility. However, the statistical power of our study was limited, large well-designed studies and further functional investigations are needed to confirm our findings.

References

Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wentao GaoAndrea Gambotto
Jan 7, 2004·Nature Reviews. Cancer·Glenn Dranoff
Nov 18, 2004·Immunological Reviews·Mark J SmythYoshihiro Hayakawa
Aug 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·D R BoothUNKNOWN Southern MS Genetics Consortium
Jan 21, 2006·World Journal of Gastroenterology : WJG·Sheng HuRui-Ping Pang
May 4, 2007·The Journal of Clinical Investigation·Wan-Wan Lin, Michael Karin
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·S Perwez Hussain, Curtis C Harris
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Oct 31, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Faming PanJianhua Xu
Jul 6, 2010·Human Immunology·Kashi N PrasadVimal K Paliwal
Oct 1, 2010·Journal of Gastroenterology and Hepatology·Huiping XueGang Huang
Oct 29, 2010·BMC Gastroenterology·Dinorah N Martínez-CarrilloGloria Fernández-Tilapa
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Eóin N McNameeJesús Rivera-Nieves
Nov 15, 2011·Journal of Gastric Cancer·Sung Joon Kwon
Sep 20, 2012·Nature Immunology·Jacques BanchereauAnne O'Garra
Nov 23, 2012·International Journal of Immunogenetics·B PeiC Ding

❮ Previous
Next ❯

Citations

May 29, 2015·International Journal of Molecular Sciences·Bao ZhangZu-Fei Feng
Sep 17, 2015·Journal of Molecular Endocrinology·Ni YanJinan Zhang
Oct 21, 2016·Microbiology and Immunology·Gamal AllamAmre Nasr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.