The variation of prognostic significance of Maximum Standardized Uptake Value of [18F]-fluoro-2-deoxy-glucose positron emission tomography in different histological subtypes and pathological stages of surgically resected Non-Small Cell Lung Carcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Christian CasaliMorandi Uliano

Abstract

Even if the prognostic role of SUVmax of 18-FDG-PET has been largely investigated, many issues regarding its relationship with pathologic staging and histological subtypes still remain controversial. This retrospective study investigated the prognostic significance of SUVmax in 119 completely resected, pathologically proven NSCLC. The SUVmax values resulted significantly related to histological subtypes (p<0.001), histological grading (p<0.001), and pathologic stage (p<0.001). The optimal cut-off value of SUVmax to predict prognosis in the whole series was 6.7 (p=0.029). 2-Year disease-specific survival (DSS) was 91% for SUVmax < or =6.7 and 55% for SUVmax >6.7 (p<0.001). SUVmax still remain a significant predictor of survival in Stage IB (2-year DSS of 100% for SUVmax < or =6.7; 51% for SUVmax >6.7, p=0.016). The optimal cut-off values of SUVmax to predict prognosis were 5 for adenocarcinoma (p=0.027) and 10.7 for other non-adenocarcinoma NSCLC subtypes (p=0.010). These histologic-specific cut-offs resulted significantly related to survival when stratified for stage: 2-year DSS for Stage IB adenocarcinoma were 100% for SUV< or =5 and 40% for SUVmax >5 (p=0.051); 2-year DSS for Stage IB non-adenocarcinoma were 83% for SUVmax < ...Continue Reading

References

Mar 4, 2000·AJR. American Journal of Roentgenology·E F PatzJ Herndon
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Sep 20, 2000·Nuclear Medicine Communications·J R LeeY Menda
Oct 12, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·K DhitalJ Dussek
Sep 13, 2002·Chest·Michael D BrundageWilliam J Mackillop
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J DowneyValerie Rusch
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Robert James CerfolioAlfred A Bartolucci
May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Angela van BaardwijkDirk De Ruysscher
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hubert VesselleDouglas E Wood
Oct 6, 2007·Chest·Anthony J AlbergUNKNOWN American College of Chest Physicians
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine M W PistersUNKNOWN American Society of Clinical Oncology
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Boone GoodgameRamaswamy Govindan
Apr 1, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·François-Xavier HaninAlain J Poncelet
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre PignonUNKNOWN LACE Collaborative Group
Aug 30, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nael Al-SarrafVincent Young
Feb 13, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hyeong Ryul KimSook Whan Sung

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Citations

Sep 8, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Roslyn FrancisLaurence Morandeau
Dec 7, 2013·Journal of Cardiothoracic Surgery·Alessandro StefaniUliano Morandi
Apr 24, 2012·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Haruhiko Nakamura
Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Takehiro SakaiIkuo Fukuda
Sep 26, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jessica L SeidelmanLeslie E Quint
Jun 6, 2014·Nuclear Medicine and Molecular Imaging·Joo Hyun OSung Hoon Kim
Nov 3, 2015·Revista española de medicina nuclear e imagen molecular·A K AyanB Seven
May 1, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yohei ImamuraHisamichi Aizawa
Jul 6, 2015·Annals of Nuclear Medicine·Takashi TanakaSusumu Kanazawa
Jan 15, 2014·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Andrzej LebiodaWieslawa Windorbska
Dec 8, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Haruhiko NakamuraMasayuki Takagi
Feb 23, 2013·American Journal of Clinical Pathology·Arthur ChoByoung Wook Choi
Nov 14, 2014·The Cochrane Database of Systematic Reviews·Mia Schmidt-HansenMarta Roqué I Figuls
Feb 3, 2016·Radiology and Oncology·Antonio NappiGiovanni Storto

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