The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications

Journal of Translational Medicine
Ning RenChen-Hao Zhou

Abstract

Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, the current detection methods of different agents' genotoxicity, along with their basic and clinical relation to human cancer, chemotherapy, germ cells and stem cells.

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Citations

Sep 28, 2020·Molecular Biology Reports·Stery Brenda OrohBugi Ratno Budiarto
Jan 11, 2021·Journal of Hazardous Materials·Iruthayapandi Selestin RajaDong-Wook Han
Mar 11, 2021·Toxicon : Official Journal of the International Society on Toxinology·Flavia Tasmin Techera AntunesAlessandra Hubner de Souza
Jun 1, 2021·Chemico-biological Interactions·Sharmistha ChoudhuriShailendra Asthana
Jul 24, 2021·Toxicological Research·Seung-Beom ChaJong-Choon Kim
Aug 28, 2021·International Journal of Environmental Research and Public Health·Federica GiambòLuca Falzone
Oct 5, 2020·Journal of Ethnopharmacology·Amina Ibrahim Dirar, Hari Prasad Devkota

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Methods Mentioned

BETA
chromosomal aberrations
MDS
transgenic
electrophoresis
Fluorescence
PCR
ubiquitination
acetylation
immunoprecipitation

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