The vasa vasorum and associated endothelial nitric oxide synthase is more important for saphenous vein than arterial bypass grafts

Angiology
Mats DreifaldtMichael R Dashwood

Abstract

No-touch (NT) saphenous vein (SV) grafts are superior to SVs harvested by the conventional technique (CT), with a patency comparable with the internal thoracic artery (ITA). Preservation of the vasa vasorum is implicated in the success of NT harvesting. We compared the vasa vasorum and endothelial nitric oxide synthase (eNOS) in NT SV with ITA and radial artery (RA) grafts. Skeletonized SV (SSV) was also analyzed. The NT SV had a higher number and larger vasa vasorum compared with ITA (P = .0001) and RA (P = .0004) that correlated with eNOS protein. Activity of eNOS in SSV grafts was significantly lower than NT SV grafts (P = 004). Since a high proportion of the vasa vasorum are removed in SSV using the CT, we suggest that preservation of the vasa vasorum and eNOS-derived NO contributes to the high patency for NT as compared with SSV grafts.

References

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Citations

Nov 1, 2003·Medical Hypotheses·T P Crotty
May 27, 2015·Trends in Endocrinology and Metabolism : TEM·Marta Gil-OrtegaMaria S Fernández-Alfonso
Oct 21, 2016·British Journal of Pharmacology·Ning Xia, Huige Li
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Jun 12, 2017·Journal of Cell Communication and Signaling·Andrzej Loesch, Michael R Dashwood
Aug 6, 2018·Journal of Cell Communication and Signaling·Andrzej Loesch, Michael R Dashwood
Dec 15, 2020·Asian Cardiovascular & Thoracic Annals·Ninos SamanoMichael R Dashwood
Mar 30, 2021·Journal of the American Heart Association·Takuma MikamiNobuyoshi Kawaharada
Jun 25, 2021·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·A V FrolovA G Kutikhin

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Methods Mentioned

BETA
coronary artery bypass
transfection

Software Mentioned

Zeiss KS400
SAS
Zeiss Axiovision

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