The vascular effects of trace amines and amphetamines

Pharmacology & Therapeutics
K J Broadley

Abstract

Trace amines, including tyramine, beta-phenylethylamine (beta-PEA), tryptamine and octopamine, are biologically active amines mostly based on phenylethylamine, occurring in the body in trace amounts. They are a diverse group of naturally occurring and synthetic amines, which are also found in the diet and in herbal plants, such as ephedrine and cathinone. They include amphetamine and its analogues, such as MDMA ('ecstasy'), and synthetic proprietary sympathomimetic agents such as phenylpropanolamine and pseudoephedrine. On the vascular system they cause vasoconstriction and a rise in blood pressure. This effect is the basis of their use as nasal decongestants. For over 50 years, they have been assumed to be indirectly acting sympathomimetic amines, their responses being due to the release of noradrenaline from sympathetic neurones. There are, however, results that suggest that this is not their only mechanism of action and that they may also exert direct vascular effects independent of a noradrenergic mechanism. Recently, a group of novel trace amine-associated receptors (TAARs) have been cloned and identified in the brain and peripheral tissues including blood vessels. Trace amines bind to these cloned receptors and it is sugg...Continue Reading

References

Aug 1, 1977·British Journal of Clinical Pharmacology·K Ghose, P Turner
Jul 1, 1975·Clinical Endocrinology·C H WalshH G Coore
Sep 1, 1992·Archives of Disease in Childhood·A R Bedford RussellS Dawling
Jul 1, 1992·Clinical and Experimental Pharmacology & Physiology·Z Y DuO L Woodman
Sep 1, 1992·Zeitschrift Für Lebensmittel-Untersuchung Und -Forschung·G ZieglederB Stumpf
Oct 1, 1992·Scottish Medical Journal·D P Harries, R De Silva
Feb 1, 1992·Pharmacology & Toxicology·P Kalix
May 2, 1991·European Journal of Pharmacology·L Zhang, D C Dyer
Apr 11, 1991·Archives of Internal Medicine·T V Parran, D R Jasinski
May 1, 1991·Cephalalgia : an International Journal of Headache·C M GibbM Sandler
Jan 15, 1991·Biochemical Pharmacology·M B Youdim, J P Finberg
Jan 1, 1991·Journal of Neural Transmission. General Section·J JarmanM Sandler
Dec 1, 1990·British Journal of Clinical Pharmacology·R BrenneisenP Kalix
Sep 1, 1989·Cellular and Molecular Neurobiology·T V Nguyen, A V Juorio
Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·R G Chess-WilliamsD J Sheridan
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·R BrenneisenX Schorno
Mar 27, 1987·JAMA : the Journal of the American Medical Association·G P DowlingR O Bost
Mar 29, 1988·European Journal of Pharmacology·S J Peroutka, A Hamik
May 1, 1988·The Journal of Laryngology and Otology·K Holmberg, M Bende
Feb 1, 1987·Journal of Pharmaceutical Sciences·F A Moya-HuffT J Maher
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Wellman, T L Sellers
Sep 1, 1986·British Journal of Pharmacology·A Vaccari
May 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A Grollman, V S Krishnamurty
Nov 1, 1974·Cardiovascular Research·P CôtéD C Harrison
Jun 16, 1974·Life Sciences·A A Boulton, L E Dyck
Mar 1, 1973·Journal of Neurochemistry·J M SaavedraJ Axelrod
May 1, 1973·European Journal of Pharmacology·J R BoissierC Advenier
Apr 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·A M MoffettD F Scott
Jul 1, 1972·European Journal of Pharmacology·E D Hendley, S H Snyder
Feb 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·A D Rudzik, J N Eble
May 1, 1982·The Journal of Pharmacy and Pharmacology·J D Kohli, L I Goldberg
Mar 1, 1983·Annals of Neurology·M R WootenM J Murphy
Jan 1, 1984·General Pharmacology·P Kalix

❮ Previous
Next ❯

Citations

Jul 17, 2013·Drugs·Christoph SchroederHoracio Kaufmann
May 15, 2013·European Journal of Pharmacology·Kenneth J BroadleyEmma J Kidd
Nov 18, 2011·Journal of the American Veterinary Medical Association·Katherine L PetersonLynn R Hovda
Feb 19, 2014·Nature Reviews. Urology·Sean C Skeldon, S Larry Goldenberg
Mar 29, 2014·Current Behavioral Neuroscience Reports·Mark J Niciu, Graeme F Mason
Jul 12, 2012·Cellular and Molecular Life Sciences : CMLS·Chi Chiu WangChristoph Ufer
Jun 7, 2014·Pharmacology Research & Perspectives·N Ayala-LopezS W Watts
Apr 17, 2012·Trends in Plant Science·Jillian M HagelPeter J Facchini
Feb 22, 2012·The International Journal on Drug Policy·Marie Claire Van Hout, Tim Bingham
Jul 14, 2010·Journal of Insect Physiology·Heleen VerlindenJozef Vanden Broeck
Dec 5, 2015·Journal of Physiology and Biochemistry·Christian CarpénéJeanne Mialet-Perez
Aug 26, 2010·Addiction·Adam R WinstockFabrizio Schifano
Sep 1, 2011·Microscopy Research and Technique·Federica FulceriMarco Gesi
Jul 19, 2012·Pest Management Science·Timothy C Marrs
Oct 7, 2015·Frontiers in Neuroscience·Tamara J Phillips, Shkelzen Shabani
Aug 11, 2011·Toxicology Letters·Sandra L HrometzJon E Sprague
Mar 30, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John EmeDane A Crossley
May 4, 2016·Journal of the American Chemical Society·Peng HuDavid Milstein
May 29, 2016·Progress in Neurobiology·S ButiniH Stark
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Zahid Khan, Waqas Nawaz
Sep 4, 2016·Allergologia et immunopathologia·I San Mauro MartinE Garicano Vilar
Oct 25, 2016·Journal of the Neurological Sciences·Ghaemeh NabaeiFarzad Fatehi
Dec 23, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Nadja WüstPeter Paulsen
Mar 11, 2016·PloS One·Seong-Il EyunEtsuko N Moriyama
Mar 14, 2017·Bioorganic & Medicinal Chemistry Letters·Yoshio Hamada
Nov 7, 2017·Chemical Communications : Chem Comm·Lu WangYoung-Tae Chang
Nov 8, 2017·Obstetrics and Gynecology·Jacqueline M CohenKrista F Huybrechts
Jun 24, 2018·Nanotoxicology·Vera L MariaMónica J B Amorim
Jul 25, 2015·The European Respiratory Journal·Swanny PerrinMarie-Camille Chaumais

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.