The vasoactive intestinal peptide-receptor system is involved in human glioblastoma cell migration

Neuropeptides
Stéphanie CochaudJean-Marc Muller

Abstract

Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor in adults. This cancer has an infiltrative nature and the median survival of patients is about one year. Vasoactive intestinal peptide (VIP) belongs to a structurally related family of polypeptides and is a major regulatory factor in the central and peripheral nervous systems. VIP regulates proliferation of astrocytes and of numerous cancer cell lines and modulates migration in prostatic and colonic cancer cell lines. Little is known about the involvement of VIP and its receptors (VIP-receptor system) in proliferation or migration of GBM cells. The effects of VIP, PACAP and of synthetic VIP antagonists were tested in two human GBM cell lines, M059K and M059J, established from two different parts of a single tumor. In these cells, the data revealed that the VIP-receptor system did not affect proliferation but controlled cell migration. Indeed, in M059K cells which express components of the VIP receptor system, the VIP receptor antagonists and a PACAP antibody enhanced migration. The VIP receptor antagonists increased generation of typical migration-associated processes: filopodia and lamellipodia, and activation of Rac1 and Cdc42 GTPases. Reciprocally, in M...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M J Allalunis-TurnerR C Urtasun
Apr 1, 1995·Molecular Neurobiology·J M MullerA C Meunier
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T W MoodyI Gozes
May 15, 1996·The Journal of Clinical Investigation·D E Brenneman, I Gozes
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C Holland
Jun 15, 2000·Journal of Molecular Neuroscience : MN·I Gozes, D E Brenneman
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Lara-MarquezB Karacay
Oct 27, 2001·Breast Cancer Research and Treatment·T W MoodyI Gozes
Feb 28, 2002·Journal of Molecular Neuroscience : MN·A SharmaT W Moody
Oct 3, 2002·Results and Problems in Cell Differentiation·Mark F Mehler
Nov 1, 2003·Journal of Molecular Neuroscience : MN·Christine DufesJean-Marc Muller
Mar 30, 2004·Brain Research. Molecular Brain Research·Yoshiyuki SakaiAkemichi Baba
Jan 28, 2005·Journal of Neuro-oncology·Tim Demuth, Michael E Berens
Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Hiroko Ohgaki, Paul Kleihues
Aug 2, 2005·Cancer Science·Daisuke YamazakiTadaomi Takenawa
May 26, 2006·Nature Reviews. Cancer·Angelo L VescoviBrent A Reynolds
Sep 23, 2006·Regulatory Peptides·Jean-Marc MullerCorinne Chadéneau
Nov 24, 2006·Neurosurgical Review·Matthew R QuigleyGarth Ehrlich
Jul 28, 2007·Peptides·Olfa Masmoudi-KoukiMarie-Christine Tonon
Apr 30, 2008·FEBS Letters·Markus Ladwein, Klemens Rottner
Feb 4, 2009·The Prostate·Ana B Fernández-MartínezMaría J Carmena

❮ Previous
Next ❯

Citations

Jul 19, 2011·World Journal of Biological Chemistry·Glenn Paul DorsamSandeep Batra
Jan 31, 2016·Peptides·Madryssa de BoisvilliersCorinne Chadéneau
Oct 9, 2014·Journal of Cellular Physiology·Yang LiuZhenhua Wang
Dec 26, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Terry W MoodyRobert T Jensen
Dec 3, 2014·Biochemical and Biophysical Research Communications·Alice BarbarinCorinne Chadéneau
Aug 28, 2016·Journal of Molecular Neuroscience : MN·Sebastian BardosiDora Reglodi
Apr 9, 2020·Frontiers in Endocrinology·Sarah FalkenstetterSerge Weis
Jan 8, 2015·Journal of Neuro-oncology·Stéphanie CochaudCorinne Chadéneau
Aug 28, 2021·Brain Sciences·Agata Grazia D'AmicoVelia D'Agata

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.