PMID: 3754963Jan 1, 1986Paper

The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea pig isolated heart

Peptides
F RiouxS St-Pierre

Abstract

Neuropeptide Y (NPY) infusions into isolated, perfused, spontaneously beating hearts of guinea pigs elicited concentration-dependent increases of myocardial perfusion pressure and decreases of myocardial tension, but no consistent changes of heart rate. The increase of perfusion pressure caused by NPY (attributed to a constrictor effect on coronary vessels) was not affected by atropine, prazosin, yohimbine, propranolol, cimetidine, diphenhydramine, indomethacin or a mixture of methysergide and morphine. However, it was reduced by verapamil, a Ca2+ antagonist. Deletion of the N-terminal amino acid Tyr1 from the NPY molecule caused a 12-fold reduction of NPY potency as a coronary constrictor. Further shortening of the NPY molecule by removal of sequence Tyr1 through Glu15 or Tyr1 through Ala18 caused major losses of potency without detectable reduction of intrinsic activity. The results suggest that the constrictor effect of NPY on guinea pig coronary vessels results from a direct effect on vascular smooth muscle cells, is mediated by specific receptors and is likely to involve the participation of extracellular calcium ions. The results also suggest that the chemical groups responsible for the vasoconstrictor effect of NPY in gu...Continue Reading

References

Jul 1, 1985·Acta Physiologica Scandinavica·A Franco-CerecedaC Dahlöf
May 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J GuS R Bloom
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto

❮ Previous
Next ❯

Citations

Jul 15, 1987·Experientia·J Wharton, S Gulbenkian
Feb 1, 1991·Cardiovascular Drugs and Therapy·D GantenR E Lang
Oct 15, 1991·European Journal of Pharmacology·A ModinJ M Lundberg
Oct 5, 1993·European Journal of Pharmacology·F J RomanJ L Junien
Nov 1, 1990·Journal of the Autonomic Nervous System·S GulbenkianJ F David-Ferreira
Mar 1, 1992·Journal of the Autonomic Nervous System·E K PotterD I McCloskey
Sep 1, 1987·Regulatory Peptides·B E DunningG J Taborsky
Jan 1, 1990·Peptides·V E EysseleinT D Lee
Jul 1, 1990·Peptides·A BalasubramaniamE M Plisetskaya
Jan 1, 1992·Progress in Neurobiology·Y DumontR Quirion
Jan 1, 1995·Brain Research Bulletin·F B JolicoéurS St-Pierre
Jul 21, 1998·European Journal of Pharmacology·A Franco-Cereceda, J Liska
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J AllenG Heinrich
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J L KrstenanskyL R McLean
Aug 1, 1992·International Journal of Dermatology·B KumarE M Farber
Mar 1, 1987·Clinical and Experimental Pharmacology & Physiology·R B MinsonJ P Chalmers
Jan 1, 1990·Clinical and Experimental Pharmacology & Physiology·R B MinsonJ P Chalmers
Sep 1, 1991·British Journal of Pharmacology·S J AwadD P Richardson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.