The vasopressin-associated glycopeptide is not a prolactin-releasing factor: studies with lactating Brattleboro rats

Endocrinology
J F HydeN Ben-Jonathan

Abstract

We have recently reported that the posterior pituitary contains PRL-releasing factor (PRF), a small (less than 5000 mol wt) peptide which induces a rapid, hormone-specific, and concentration-dependent stimulation of PRL secretion. Although the identity of posterior pituitary PRF is yet unknown, it is distinct from known PRL secretagogues. Recently, the vasopressin-associated glycopeptide (VAG), which is concentrated in the posterior pituitary, was suggested as a PRF. To investigate whether VAG functions as a PRF, we used Brattleboro rats, which are deficient in arginine vasopressin (AVP), AVP-associated neurophysin, and VAG. Homozygous (DI) and heterozygous (HZ) lactating Brattleboro rats were used. The water consumption of pregnant DI rats (greater than 300 ml/day) was 6-fold higher than that of HZ rats. To correct their water imbalance, DI rats were implanted with osmotic minipumps containing the vasopressin analog 1-desamino-8-D-arginine vasopressin. On days 7-8 of lactation, pups were separated for 6 h, and blood was collected from the dams via a jugular cannula. Upon introduction of the pups, plasma PRL levels increased 100-fold in both DI and HZ rats and remained elevated for the duration of suckling. The suckling-induced...Continue Reading

Citations

Jan 1, 1994·Peptides·H Houben, C Denef
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Aug 15, 2013·The Journal of Endocrinology·Anna FodorDóra Zelena
May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·M Christ-CrainW Fenske
Jan 23, 2016·Nature Reviews. Endocrinology·Mirjam Christ-Crain, Wiebke Fenske
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Aug 26, 2006·Peptides·Luciano Debeljuk, Mercedes Lasaga
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Aug 2, 2019·Journal of Endocrinological Investigation·M Christ-Crain, W K Fenske
Oct 28, 2019·Reviews in Endocrine & Metabolic Disorders·Mirjam Christ-Crain
Aug 28, 2020·Pituitary·Juliana B DrummondAntonio Ribeiro-Oliveira

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