The vasoregulatory role of endothelium derived nitric oxide during pulsatile cardiopulmonary bypass

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
M MachaB G Hattler

Abstract

The role of pulsatile flow as a physiologic stimulus for endothelium mediated vasoregulation is poorly understood. Furthermore, non pulsatile flow, which is associated with increased vascular resistance and end-organ failure, has been demonstrated to lead to a decrease in nitric oxide (NO) production in vitro. Anesthetized pigs (23.4 +/- 0.3 kg) were placed on cardiopulmonary bypass using either non pulsatile or pulsatile perfusion for 60 min. In both groups, animals were maintained with a constant mean aortic flow (1.0-1.3 L/min). Serum samples obtained during bypass were assayed for the stable end-products of NO (nitrate [NO3-] and nitrite [NO2-]) by a method based on the Greiss reaction. Systemic vascular resistance was higher after 60 min in the non pulsatile (3712.5 +/- 481.2 dyne sec cm(-5)) vs the pulsatile group (2672.6 +/- 427.0 dyne sec cm(-5)), but not statistically significant (p > .05). However, NO production was decreased in the non pulsatile flow group (27 +/- 6%) vs the pulsatile flow group (14 +/- 5%) at a statistically significant level (p < .005). The results suggest that non pulsatile flow is associated with diminished endothelial shear stress and a reduction in endothelial nitric oxide production. This may ...Continue Reading

Citations

Apr 8, 2006·Current Hypertension Reports·Gordon S Stokes
Feb 13, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Francesco OnoratiAttilio Renzulli
Mar 27, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Giuseppe Filiberto SerrainoAttilio Renzulli
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M IngyinnM Viswanathan
Jul 28, 2012·The Annals of Thoracic Surgery·Michael P O'NeilLinrui Ray Guo
Apr 10, 2004·The Journal of Clinical Hypertension·Gordon S Stokes
Jun 3, 2009·Revista brasileira de anestesiologia·Célio Gomes de AmorimMaria José Carvalho Carmona
Feb 28, 2004·Journal of Biomechanical Engineering·F Carroll DoughertyMary I Townsley
Mar 23, 2019·Artificial Organs·Takuma MiyamotoKiyotaka Fukamachi
May 26, 2005·Anesthesiology·Robert M BryanSean P Marrelli

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