The VDAC channel: Molecular basis for selectivity

Biochimica Et Biophysica Acta
M Colombini

Abstract

The voltage dependent anion-selective channel, VDAC, is the major permeability pathway by which molecules and ion cross the mitochondrial outer membrane. This pathway has evolved to optimize the flow of these substances and to control this flow by a gating process that is influenced by a variety of factors including transmembrane voltage. The permeation pathway formed through the membrane by VDAC is complex. Small ion flow is primarily influenced by the charged surface of the inner walls of the channel. Channel closure changes this landscape resulting in a change from a channel that favors anions to one that favors cations. Molecular ions interact more intimately with the inner walls of the channel and are selected by their 3-dimensional structure, not merely by their size and charge. Molecular ions typically found in cells are greatly favored over those that are not. For these larger structures the channel may form a low-energy translocation path that complements the structure of the permeant. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou.

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Citations

Jun 7, 2016·Biochimica Et Biophysica Acta·Pierre SonveauxJean-Claude Martinou
Jan 15, 2017·Biochimica Et Biophysica Acta. Bioenergetics·Alberto DanesePaolo Pinton
Apr 12, 2018·Biosensors·Bernhard Schuster
Sep 29, 2018·International Journal of Molecular Sciences·Marju PuurandTuuli Kaambre
Apr 19, 2019·Future Medicinal Chemistry·Andonis Karachitos, Hanna Kmita
Mar 25, 2020·Sensors·Samar Damiati, Bernhard Schuster
Mar 25, 2020·Archives of Toxicology·Wing-Kee Lee, Frank Thévenod
Apr 28, 2020·Critical Reviews in Biotechnology·Poonam KanwarGirdhar K Pandey
Aug 14, 2019·Journal of Biomolecular NMR·Matthew T EddyRobert G Griffin
Dec 14, 2019·Proteins·Maximilien Lopes-RodriguesCatherine Michaux
May 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luc RochetteCatherine Vergely
Jun 30, 2019·The Journal of Biological Chemistry·Maria TalmonLuigia G Fresu
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Frank ThévenodMichael D Garrick
Jul 26, 2017·Frontiers in Oncology·Cristina MammucariRosario Rizzuto
Mar 16, 2018·Pflügers Archiv : European journal of physiology·Cristina MammucariRosario Rizzuto
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Hyunsu JungSeok-Kyu Kwon
Feb 12, 2021·International Journal of Molecular Sciences·Carmen A Mannella
Feb 8, 2021·Cell Calcium·Agnese De MarioCristina Mammucari
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Matthew L BlankJon P Boyle
Apr 4, 2021·International Journal of Molecular Sciences·Hayet SaidaniFabrice Homblé
Jun 8, 2021·Frontiers in Physiology·Maria Carmela Di RosaVito De Pinto
Jul 24, 2021·Physical Chemistry Chemical Physics : PCCP·Anna Puiggalí-JouCarlos Alemán
Aug 13, 2021·Advanced Biology·Hariharan Murali MahadevanAngelika Bettina Harbauer
Aug 19, 2021·Journal of Computer-aided Molecular Design·F Van LiefferingeM Prévost
Aug 17, 2021·Cell Calcium·Dmitry LimAlexei Verkhratsky
Sep 11, 2021·ACS Chemical Neuroscience·Altmash KhanRadhakrishnan Mahalakshmi

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