The VEGF and PEDF levels in the follicular fluid of patients co- treated with LETROZOLE and gonadotropins during the stimulation cycle

Reproductive Biology and Endocrinology : RB&E
Jigal HaasRobert F Casper

Abstract

Previous studies have shown that androgens, in addition to serving as precursors for ovarian estrogen synthesis, also have a fundamental role in primate ovarian follicular development by augmentation of FSH receptor expression on granulosa cells. Recent studies have shown that aromatase inhibitor, letrozole, improves ovarian response to FSH in normal and poor responder patients, possibly by increasing intraovarian androgen levels. Studies in mice also showed an effect of letrozole to increase pigment epithelium-derived factor (PEDF) and to lower vascular epithelial growth factor (VEGF), which might be expected to reduce the risk of ovarian hyperstimulation syndrome (OHSS) with stimulation. The aim of this study was to compare the VEGF and PEDF levels in the follicular fluids of normal responders treated with letrozole and gonadotropins during the ovarian stimulation with patients treated with gonadotropins only. A single center, prospective clinical trial. We collected follicular fluid from 26 patients, on a GnRH antagonist protocol, dual triggered with hCG and GnRH agonist. The patients in one group were co-treated with letrozole and gonadotropins during the ovarian stimulation and the patients in the other group were treated ...Continue Reading

References

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Sep 1, 2017·Reproductive Biology and Endocrinology : RB&E·Jigal HaasRobert F Casper

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Citations

Jul 28, 2020·Journal of Assisted Reproduction and Genetics·Bruce I Rose, Samuel E Brown
Nov 15, 2020·Annals of the New York Academy of Sciences·Konstantinos SfakianoudisMara Simopoulou
May 6, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Luba NemerovskyRuth Shalgi
Jun 28, 2021·Journal of Medical Case Reports·Haipeng HuangHiroyuki Seki
Dec 30, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jie ZhangNingning Wang

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Methods Mentioned

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