The Vehicle Determines the Destination: The Significance of Seminal Plasma Factors for Male Fertility.

International Journal of Molecular Sciences
Fengli WangShuiqiao Yuan

Abstract

Of all human infertility cases, up to 50% show contributing factors leading to defects in the male reproductive physiology. Seminal plasma (SP) is the biological fluid derived from the male accessory sex gland which carries spermatozoa passing throughout the male and female reproductive tract during ejaculation. It contains a complicated set of heterogeneous molecular structures, including proteins, cell-free nucleic acid (DNA, microRNA and LncRNA), and small-molecule metabolites as well as inorganic chemicals (ions). For a long time, the substantial significance of seminal plasma factors' functions has been underestimated, which is restricted to spermatozoa transport and protection. Notably, significant advancements have been made in dissecting seminal plasma components, revealing new insights into multiple aspects of sperm function, as well as fertilization and pregnancy outcomes in recent years. In this review, we summarize the state-of-art discoveries regarding SP compositions and their implications in male fertility, particularly describing the novel understanding of seminal plasma components and related modifications using "omics" approaches and mainly focusing on proteome and RNA-seq data in the latest decade. Meanwhile,...Continue Reading

References

Jun 1, 1975·The Tohoku Journal of Experimental Medicine·M ShiraiK Yonezawa
Jul 1, 1990·Andrologia·J NeuwingerE Nieschlag
Jul 1, 1988·Journal of Reproductive Immunology·S SaxenaA Farooq
Apr 1, 1987·Fertility and Sterility·S H BrennerG Weiss
Apr 1, 1986·American Journal of Obstetrics and Gynecology·G WeissR D'Eletto
Sep 1, 1985·Fertility and Sterility·J B LessingG Weiss
Mar 1, 1970·Fertility and Sterility·K H Moon, R G Bunge
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·D AdamopoulosH H McGarrigle
Jan 1, 1982·Annals of the New York Academy of Sciences·M EssigG Weiss
Jun 1, 1994·Fertility and Sterility·R K Naz, A C Menge
Aug 1, 1993·The Anatomical Record·B E KurthJ C Herr
Jan 1, 1993·Human Reproduction·L BujanC Sultan
Jul 20, 1999·Molecular and Cellular Endocrinology·L T BudnikA K Mukhopadhyay
Jul 21, 1999·Cellular and Molecular Life Sciences : CMLS·M Robert, C Gagnon
Jan 29, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E CaroppoG D'Amato
May 15, 2003·The Prostate·Angelita G UtlegBiaoyang Lin
May 17, 2003·Fertility and Sterility·Ashok AgarwalMohamed A Bedaiwy
Jan 28, 2005·Journal of Assisted Reproduction and Genetics·Jennifer S ChouPhilip J Chan
May 11, 2005·The Journal of Biological Chemistry·Philip C N ChiuWilliam S B Yeung
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Feb 19, 2008·Human Reproduction Update·Kelton Tremellen
Feb 19, 2008·Human Reproduction·Juan Martínez-HerediaRafael Oliva
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Srividya SeshadriD I Lewis Jones
Apr 16, 2011·Human Reproduction Update·S GurunathSiladitya Bhattacharya
Sep 10, 2011·Journal of Andrology·Alberto FerlinCarlo Foresta

❮ Previous
Next ❯

Citations

Apr 4, 2021·International Journal of Molecular Sciences·Manuel Álvarez-Rodríguez, Felipe Martinez-Pastor
May 1, 2021·International Journal of Molecular Sciences·Heriberto Rodriguez-MartinezJordi Roca

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq
electrophoresis
chip
testosterone replacement therapy
biopsy

Software Mentioned

SpermCheck
SpermCheck Fertility

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Reproductive Biology and Endocrinology : RB&E
Luna SamantaAshok Agarwal
Nature Reviews. Urology
Andrei P DrabovichEleftherios P Diamandis
Basic and Clinical Andrology
Mariana CamargoRicardo Pimenta Bertolla
Animal Reproduction Science
X Druart, S P de Graaf
© 2021 Meta ULC. All rights reserved