The velocity of antihypertensive effect of losartan/hydrochlorothiazide and angiotensin II receptor blocker

Journal of Hypertension
Hirohito MetokiJ-HOME-AI Study group

Abstract

The hypotensive effect and the time to attain the maximum antihypertensive effect (stabilization time) of losartan/hydrochlorothiazide (HCTZ) combination therapy and therapy with a maximal dose of angiotensin II receptor blockers (ARBs) in patients who failed to achieve adequate blood pressure (BP) control on a medium-dose of ARBs were compared by analyzing exponential decay functions using daily serial morning home BP measurements. Essential hypertensive patients treated with a medium dose of ARB, in whom a target home SBP (135 mmHg) was not achieved, were randomized into two groups: a combination group (n = 110) and a maximal-dose ARB group (n = 111). The combination therapy provided additional reduction of 5.2 mmHg [95% confidence interval (CI) 1.8 to 8.5 mmHg, P = 0.003] in home SBP over the maximal-dose ARB therapy in 8 weeks after randomization. A greater reduction in the home SBP values was seen in the combination group than in the maximal-dose ARB group from the second day after randomization on the basis of a linear mixed model. The maximum antihypertensive effect and stabilization time for home SBP were 10.9 ± 5.0 mmHg and 7.3 ± 29.7 days, respectively, in the combination group, whereas the corresponding values in the...Continue Reading

References

Dec 18, 1976·Lancet·G JacksonJ Condon
May 20, 1999·Journal of Human Hypertension·J L PoolM Gatlin
Mar 16, 2001·The American Journal of Cardiology·R A KlonerUNKNOWN Comparison of Candesartan and Amlodipine for Safety, Tolerability and Efficacy (CASTLE) Study Investigators
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yutaka ImaiUNKNOWN Japanese Society of Hypertension
Mar 6, 2004·American Journal of Hypertension·Steven G ChrysantDonald J Hinman
Aug 7, 2007·The American Journal of Medicine·Sripal BangaloreFranz H Messerli
Oct 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takao SarutaKihito Takahashi
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators

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Citations

Apr 19, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yutaka ImaiTakayoshi Ohkubo
Mar 15, 2014·Clinical and Experimental Hypertension : CHE·Minako SakakiKimika Arakawa
Oct 2, 2014·Clinical and Experimental Hypertension : CHE·Hirohito MetokiUNKNOWN Japan-Home versus Office Blood Pressure Measurement Evaluation – Augmentation Index Study Investigators
Jun 15, 2013·Clinical and Experimental Pharmacology & Physiology·Yutaka ImaiMichihiro Satoh
Jun 5, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Miki HosakaYutaka Imai
Apr 28, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigemasa TaniToshio Kushiro
May 8, 2018·Journal of the American Heart Association·Tomohiro HanazawaUNKNOWN HOMED‐BP (Hypertension Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure) Investigators
Mar 25, 2016·Journal of the American Heart Association·Kei AsayamaUNKNOWN Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators
Apr 28, 2016·Journal of Hypertension·Eamon Dolan, Eoin O'Brien

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