The ventral subiculum modulation of prepulse inhibition is not mediated via dopamine D2 or nucleus accumbens non-NMDA glutamate receptor activity

European Journal of Pharmacology
F J WanN R Swerdlow

Abstract

Prepulse inhibition of the acoustic startle reflex is an operational measure of sensorimotor gating. The neural substrates of prepulse inhibition may be relevant to the pathophysiology of neuropsychiatric disorders that are characterized by sensorimotor gating deficits, including schizophrenia. Studies have demonstrated abnormalities within the hippocampal formation of schizophrenia patients, and animal studies have revealed that the hippocampus, and specifically the ventral subiculum, regulates prepulse inhibition. The ventral subiculum sends a dense glutamatergic projection to the nucleus accumbens, and the nucleus accumbens is known to potently regulate prepulse inhibition via dopaminergic and non-N-methyl-D-aspartate (non-NMDA) glutamatergic mechanisms. In the present study, we examined whether the hippocampal regulation of prepulse inhibition is mediated through subiculo-accumbens glutamatergic efferents. Intra-ventral subiculum infusion of NMDA dose dependently reduced prepulse inhibition, and this effect of NMDA was reversed by co-infusion of the NMDA receptor antagonist D,L-amino-5-phosphonovaleric acid (AP5). The prepulse inhibition-disruptive effect of intra-ventral subiculum NMDA infusion was not prevented by infusio...Continue Reading

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Citations

Apr 16, 2004·Behavioural Brain Research·Sidse Marie ArnfredRalf Peter Hemmingsen
Aug 26, 1998·Biological Psychiatry·M Koch, U Ebert
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·T BastI M White
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Sep 10, 2003·Progress in Neurobiology·Tobias Bast, Joram Feldon
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Jul 12, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yosefu ArimeIchiro Sora
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Jul 23, 1999·Annals of the New York Academy of Sciences·N R SwerdlowM A Geyer
Jun 5, 2013·Hippocampus·Marc T PisanskyMichael K Georgieff
May 12, 2012·Neuropharmacology·Dean T AchesonVictoria B Risbrough
Dec 23, 2008·Behavioural Brain Research·Kuei Y TsengBarbara K Lipska

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