PMID: 7011710Jan 1, 1981Paper

The ventromedullary hypotensive effect of muscimol in the anaesthetized cat

Clinical and Experimental Hypertension : CHE
P BousquetJ Schwartz

Abstract

Muscimol, a rigid analogue of GABA, was injected into the CNS of urethane-anaesthetized, normotensive cats. Bilateral microinjections of a small dose of muscimol (100 ng/kg, 0.5 microliter on each side) in the nucleus reticularis lateralis (NRL) induced hypotension. The marked fall in blood pressure obtained by injecting 1 microgram/kg of muscimol unilaterally into the NRL is completely reversed by subsequent local administration of bicuculline (5 microgram/kg, 0.5 microliter), a specific GABA antagonist. These data confirm that a GABAergic inhibitory system modulates the pressor tonic structures localized in the region of the NRL and that the anteroventral part of the medulla oblongata includes a trigger zone for the hypotensive action of muscimol.

References

Apr 1, 1977·Journal of Neurochemistry·S J Enna, S H Snyder
Dec 1, 1977·European Journal of Pharmacology·M J Antonaccio, D G Taylor
Jan 1, 1978·British Journal of Pharmacology·W Feldberg, M Rocha e Silva
Apr 1, 1978·European Journal of Pharmacology·M J Leach, J A Wilson
Jun 1, 1976·The Journal of Physiology·W Feldberg, P G Guertzenstein
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Jul 1, 1972·The Journal of Physiology·W Feldberg, P G Guertzenstein
Jul 25, 1980·European Journal of Pharmacology·P BousquetJ Schwartz

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Citations

Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·P BousquetJ Schwartz
Dec 3, 1981·European Journal of Pharmacology·P BousquetJ Schwartz
Aug 9, 1988·European Journal of Pharmacology·D SolignacM A Enero
Nov 1, 1985·Journal of the Autonomic Nervous System·P BousquetJ Schwartz
Jan 1, 1987·General Pharmacology·G K MathesonG Tunnicliff
Oct 15, 1984·European Journal of Biochemistry·D Atlas, Y Burstein
Nov 1, 1986·Neuropharmacology·G K MathesonG Tunnicliff
Aug 15, 1983·Experientia·F V DeFeudis
Dec 22, 1985·The Journal of Comparative Neurology·C A RossD J Reis
Apr 18, 2013·Journal of Acupuncture and Meridian Studies·Peng Li, Stephanie C Tjen-A-Looi

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