PMID: 8587127Dec 1, 1995Paper

The vertebrate linker histones H1 zero, H5, and H1M are descendants of invertebrate "orphon" histone H1 genes

Journal of Molecular Evolution
E Schulze, B Schulze

Abstract

We investigated the evolutionary history of the divergent vertebrate linker histones H1 zero, H5, and H1M. We observed that the sequence of the central conserved domain of these vertebrate proteins shares characteristic features with histone H1 proteins of plants and invertebrate animals which otherwise never appear in any vertebrate histone H1 protein. A quantitative analysis of 58 linker histone sequences also reveals that these proteins are more similar to invertebrate and plant histone H1 than to histone H1 of vertebrates. A phylogenetic tree deduced from an alignment of the central domain of all known linker histones places H1 zero, H5, and H1M in close vicinity to invertebrate sperm histone H1 proteins and to invertebrate histone H1 proteins encoded by polyadenylated mRNAs. We therefore conclude that the ancestors of the vertebrate linker histones H1 zero, H5, and H1M diverged from the main group of histone H1 proteins before the vertebrate type of histone H1 was established in evolution. We discuss this observation in the general context of linker histone evolution.

Citations

Apr 30, 2008·Journal of Molecular Evolution·Rodrigo González-RomeroJosé M Eirín-López
Sep 22, 2009·Genome Génome / Conseil National De Recherches Canada·Rodrigo González-RomeroJosé M Eirín-López
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nikhil RaghuramMichael J Hendzel
Dec 23, 1999·The Journal of Biological Chemistry·A GunjanD T Brown
Nov 9, 2006·The Angle Orthodontist·Bernd G LapatkiIrmtrud E Jonas
Nov 5, 1999·Molecular Reproduction and Development·F ZhangJ Ausió
Mar 21, 1998·Developmental Genetics·H J ClarkeO A Mohamed
Jul 16, 2004·Molecular Biology and Evolution·José M Eirín-LópezJosefina Méndez
Apr 15, 2006·Molecular Biology and Evolution·José M Eirín-LópezJuan Ausió
May 25, 2005·The Journal of Biological Chemistry·John P H Th'ngMichael J Hendzel

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