The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Tupur RahmanRichard P Bazinet

Abstract

Polyunsaturated fatty acids (PUFA), especially docosahexaenoic and arachidonic acids, as well as cholesterol are important for neural development and maintaining brain function. However, in contrast to cholesterol, the brain is unable to synthesize the required amounts of these PUFA de novo and requires a constant supply from plasma. Suggested pools of uptake include plasma unesterified PUFA or the uptake of PUFA-containing lipoproteins via lipoprotein receptors into endothelial cells of the blood brain barrier. Our study tested whether the very low density lipoprotein receptor (VLDLr) is necessary for maintaining brain PUFA and cholesterol concentrations. Moreover, since VLDLr knockout (VLDLr(-/-)) mice have been reported to have behavioural deficits, this study asked the question whether altered brain PUFA and cholesterol concentrations might be related to these deficits. VLDLr(-/-) and wild-type mice had ad libitum access to chow. At 7 weeks of age the mice were sacrificed, and the cortex, cerebellum, hippocampus, and the remainder of the brain were isolated for total fatty acid and cholesterol analyses. There were no differences in total lipid PUFA or cholesterol concentrations in any of the four brain regions between VLDLr...Continue Reading

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Citations

Nov 12, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Miki IgarashiStanley I Rapoport
Nov 6, 2013·Trends in Endocrinology and Metabolism : TEM·Hong Wang, Robert H Eckel
Mar 29, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaChristopher E Ramsden
Sep 4, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaYewon Cheon
Jul 4, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Alex P KitsonRobin E Duncan
May 3, 2016·The Journal of Nutritional Biochemistry·Alex P KitsonRichard P Bazinet
Jul 6, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Chuck T Chen, Richard P Bazinet
May 15, 2016·Biochimica Et Biophysica Acta·Papasani V SubbaiahJ Michael O'Donnell
Feb 16, 2019·Molecular Nutrition & Food Research·Raphaël Chouinard-WatkinsRichard P Bazinet
Jan 7, 2018·Molecular Aspects of Medicine·R J Scott LacombeRichard P Bazinet

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