The vesicular integral protein-like gene is essential for development of a mechanosensory system in zebrafish

Developmental Neurobiology
Mabel ChongPierre Drapeau

Abstract

The zebrafish hi472 mutation is caused by a retroviral insertion into the vesicular integral protein-like gene, or zVIPL, a poorly studied lectin implicated in endoplasmic reticulum (ER)-Golgi trafficking. A mutation in the shorter isoform of zVIPL (zVIPL-s) results in a reduction of mechanosensitivity and consequent loss of escape behavior. Here we show that motoneurons and hindbrain reticulospinal neurons, which normally integrate mechanosensory inputs, failed to fire in response to tactile stimuli in hi472 larvae, suggesting a perturbation in sensory function. The hi472 mutant larvae in fact suffered from a severe loss of functional neuromasts of the lateral line mechanosensory system, a reduction of zVIPL labeling in support cells, and a reduction or even a complete loss of hair cells in neuromasts. The Delta-Notch signaling pathway is implicated in cellular differentiation of neuromasts, and we observed an increase in Notch expression in neuromasts of hi472 mutant larvae. Treatment of hi472 mutant larvae with DAPT, an inhibitor of Notch signaling, or overexpression of the Notch ligand deltaB in hi472 mutant blastocysts produced partial rescue of the morphological defects and of the startle response behavior. We conclude th...Continue Reading

References

Mar 15, 1985·The Journal of Comparative Neurology·W K MetcalfeE Schabtach
Dec 1, 1994·Developmental Biology·M A Muskavitch
Aug 1, 1994·Trends in Genetics : TIG·G Hauptmann, T Gerster
Apr 15, 1994·Science·A CollazoP M Mabee
Feb 1, 1996·Current Opinion in Neurobiology·J Lewis
Aug 1, 1995·Molecular and Cellular Neurosciences·A B Chitnis
Dec 19, 1998·Journal of Neurobiology·L Saint-Amant, P Drapeau
Jun 12, 1999·Science·N A BerminghamH Y Zoghbi
Jun 24, 1999·Journal of Neuroscience Methods·P DrapeauL Saint-Amant
Jul 6, 2000·FEBS Letters·H HauriO Nufer
Dec 9, 2000·Developmental Biology·J S Mumm, R Kopan
Jan 9, 2001·Journal of Neurochemistry·H F DoveyJ E Audia
Jun 29, 2001·Mechanisms of Development·N GompelA Ghysen
Jun 30, 2001·Journal of Neurophysiology·R R Buss, P Drapeau
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·R KollmarA J Hudspeth
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nicolas B DavidAlain Ghysen
Nov 27, 2002·Progress in Neurobiology·Pierre DrapeauEdna Brustein
Mar 17, 2004·Current Opinion in Neurobiology·Alain Ghysen, Christine Dambly-Chaudière
Apr 15, 2004·Developmental Biology·Qin LiJohn Y Kuwada
Jan 21, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ajay Chitnis
Jan 24, 2006·Nature Reviews. Neuroscience·Angeliki Louvi, Spyros Artavanis-Tsakonas
May 9, 2006·Developmental Biology·Andres F SarrazinMiguel L Allende
Jun 3, 2006·Journal of Cellular Physiology·Magali KitzmannGilles Carnac
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
May 18, 2007·Developmental Neurobiology·Mabel Chong, Pierre Drapeau
May 1, 1997·Development Genes and Evolution·J Westin, M Lardelli

❮ Previous
Next ❯

Citations

May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Steve M NelsonDeborah L Stenkamp
May 16, 2013·Psychology and Psychotherapy·Ueli KramerMartin Drapeau
Oct 12, 2012·Journal of Clinical Psychology·Ueli KramerJean-Nicolas Despland
Jun 29, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Giuseppe MontalbanoBasilio Randazzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Nicolas B DavidA Ghysen
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Eva Y MaDavid W Raible
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Eduardo J VillablancaMiguel L Allende
© 2022 Meta ULC. All rights reserved